An enclosure for electronic device, includes a chassis and a cover. The chassis defines an opening. The chassis includes a drive bracket mounted therein. The drive bracket includes a side plate facing the opening. A through hole is defined in the side plate. A rotating member is pivotally mounted on the side plate. The rotating member includes a positioning pin. A data storage device is received in the drive bracket. The data storage device defines a locking hole in alignment with the through hole of the side plate. The cover is mounted on the chassis to cover the opening of the chassis. The cover abuts the rotating member so that the positioning pin is inserted in the through hole and the locking hole to secure the data storage device in the drive bracket of the chassis.