Invention Application
US20100178246A1 TECHNETIUM- AND RHENIUM-BIS(HETEROARYL) COMPLEXES AND METHODS OF USE THEREOF FOR INHIBITING PSMA
有权
技术和RHENIUM-BIS（HETEROARYL）复合物及其用于抑制PSMA的方法
- Patent Title: TECHNETIUM- AND RHENIUM-BIS(HETEROARYL) COMPLEXES AND METHODS OF USE THEREOF FOR INHIBITING PSMA
- Patent Title (中): 技术和RHENIUM-BIS（HETEROARYL）复合物及其用于抑制PSMA的方法
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Application No.: US12631337Application Date: 2009-12-04
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Publication No.: US20100178246A1Publication Date: 2010-07-15
- Inventor: John W. Babich , Craig Zimmerman , John Joyal , Kevin P. Maresca , Genliang Lu , Shawn Hillier
- Applicant: John W. Babich , Craig Zimmerman , John Joyal , Kevin P. Maresca , Genliang Lu , Shawn Hillier
- Assignee: Molecular Insight Pharmaceuticals, Inc.
- Current Assignee: Molecular Insight Pharmaceuticals, Inc.
- Main IPC: A61K51/04
- IPC: A61K51/04 ; C07D403/12 ; C07F13/00 ; C07D401/12 ; A61K31/555 ; A61K49/00 ; C07D213/56 ; A61P25/18 ; A61P29/00 ; A61P13/08 ; A61P35/00
Abstract:
A compound of Formula I, a pharmaceutically acceptable salt, or solvate thereof: complexes with metals such as rhenium, technetium, and others to provide a complex for imaging tissues or treating disease, particularly where the metal is radioactive. Such complexes are specific to PSMA protein and can therefore be used in imaging or treating cancer of the prostate and other tissue where the protein is expressed.
Public/Granted literature
- US08211401B2 Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof for inhibiting PSMA Public/Granted day:2012-07-03
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