发明申请
- 专利标题： PYRIMIDINEDIAMINE KINASE INHIBITORS
- 专利标题（中）： 吡啶二胺激酶抑制剂
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申请号： US12649073申请日： 2009-12-29
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公开(公告)号： US20100179134A1公开(公告)日： 2010-07-15
- 发明人: Rajinder Singh , Andy Atuegbu , John Ramphal , Hui Li , Marina Gelman , Jeffrey Clough , Carlos Valdez , Somasekhar Bhamidipati , Sambaiah Thota , Darren McMurtrie
- 申请人： Rajinder Singh , Andy Atuegbu , John Ramphal , Hui Li , Marina Gelman , Jeffrey Clough , Carlos Valdez , Somasekhar Bhamidipati , Sambaiah Thota , Darren McMurtrie
- 申请人地址： US CA South San Francisco
- 专利权人： Rigel Pharmaceuticals, Inc.
- 当前专利权人： Rigel Pharmaceuticals, Inc.
- 当前专利权人地址： US CA South San Francisco
- 主分类号： A61K31/5415
- IPC分类号： A61K31/5415 ; C07D413/14 ; A61K31/538 ; C07D417/14 ; A61P35/00
摘要：
The present invention provides pyrimidinediamine compounds useful for inhibiting kinase activity, including the activity of polo-like kinase 1 (PLK1). Also provided are pharmaceutical compositions comprising these compounds and methods of treating diseases associated with kinase activity, in particular enhanced PLK1 catalytic activity, such as diseases associated with abnormal cell proliferation, including neoplastic disorders.
公开/授权文献
- US08278299B2 Pyrimidinediamine kinase inhibitors 公开/授权日：2012-10-02
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