发明申请
US20100183620A1 COMPOSITIONS AND METHODS FOR REGULATING COLLAGEN AND SMOOTH MUSCLE ACTIN EXPRESSION BY SERPINE2
审中-公开
SERPINE2调节胶原和丝氨酸肌酸激酶表达的组合物和方法
- 专利标题： COMPOSITIONS AND METHODS FOR REGULATING COLLAGEN AND SMOOTH MUSCLE ACTIN EXPRESSION BY SERPINE2
- 专利标题（中）： SERPINE2调节胶原和丝氨酸肌酸激酶表达的组合物和方法
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申请号： US12626534申请日： 2009-11-25
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公开(公告)号： US20100183620A1公开(公告)日： 2010-07-22
- 发明人: KAUMUDI BHAWE , Elizabeth Bosch , Kathleen Boyle , Arthur Brace , Anuk Das , Francis Farrell , Pitchumani Sivakumar , Jeffrey Finer , Kristen Pierce , Kathleen M. Sullivan , Brian Wong
- 申请人： KAUMUDI BHAWE , Elizabeth Bosch , Kathleen Boyle , Arthur Brace , Anuk Das , Francis Farrell , Pitchumani Sivakumar , Jeffrey Finer , Kristen Pierce , Kathleen M. Sullivan , Brian Wong
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K31/7088 ; A61K38/02 ; A61K38/16 ; A61P21/00 ; C12Q1/68
摘要：
The invention encompasses methods and compositions for increasing or decreasing collagen 1A1 expression and/or α-smooth muscle actin expression in lung fibroblasts using SERPINE2 and antagonists of SERPINE2. The invention also encompasses methods and compositions for increasing or decreasing the formation of myofibroblasts. The invention further provides methods and compositions for treatment of lung diseases, such as idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease.
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