Invention Application
- Patent Title: Mannose immunogens for HIV-1
- Patent Title (中): 用于HIV-1的甘露糖免疫原
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Application No.: US12656550Application Date: 2010-02-03
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Publication No.: US20100183669A1Publication Date: 2010-07-22
- Inventor: Raymond A. Dwek , Pauline M. Rudd , Gayle E. Ritchie , Christopher Scanlan , M.D. Max Crispin
- Applicant: Raymond A. Dwek , Pauline M. Rudd , Gayle E. Ritchie , Christopher Scanlan , M.D. Max Crispin
- Assignee: University of Oxford
- Current Assignee: University of Oxford
- Main IPC: A61K39/21
- IPC: A61K39/21
Abstract:
Methods of producing a carbohydrate HIV vaccine or immunogenic composition are provided. One method comprises expressing a glycoprotein with a modified glycosylation, which facilitates binding of the glycoprotein to the 2G12 antibody. Another method comprises iteratively selecting cells with a high affinity for the 2G12 antibody.
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