发明申请
US20100190150A1 Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators
审中-公开
用于确定对表皮生长因子受体调节剂敏感性的生物标志物和方法
- 专利标题： Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators
- 专利标题（中）： 用于确定对表皮生长因子受体调节剂敏感性的生物标志物和方法
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申请号： US10585261申请日： 2005-01-07
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公开(公告)号： US20100190150A1公开(公告)日： 2010-07-29
- 发明人: Edwin A. Clark , Shirin K. Ford , Suganthy Yoganathan , Donald G. Jackson
- 申请人： Edwin A. Clark , Shirin K. Ford , Suganthy Yoganathan , Donald G. Jackson
- 专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 国际申请： PCT/US2005/000638 WO 20050107
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
EGFR biomarkers useful in a method for identifying a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises (a) exposing the mammal to the EGFR modulator and (b) measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in (b) compared to the level of the biomarker in a mammal that has not been exposed to the EGFR modulator indicates that the mammal will respond therapeutically to the method of treating cancer.
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