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公开(公告)号：US07358074B2
公开(公告)日：2008-04-15
申请号：US11143984
申请日：2005-06-02
申请人： Donald G. Jackson , Chandra S. Ramanathan , Liana Lee , Nathan Siemers , Suzanne J. Suchard , Joshua Finger , C. Gordon Todderud , Dana Banas
发明人： Donald G. Jackson , Chandra S. Ramanathan , Liana Lee , Nathan Siemers , Suzanne J. Suchard , Joshua Finger , C. Gordon Todderud , Dana Banas
CPC分类号： G06F19/16 , A61K38/00 , C07K2319/00 , C07K2319/30 , C12N9/16 , C12Q1/6883 , C12Q2600/158 , C12Y301/03048 , G01N33/573 , G01N33/6893 , G01N2333/916 , G01N2500/00 , G01N2500/04 , Y02A90/26
摘要： The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供编码人磷酸酶多肽，其片段和同源物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型人磷酸酶多肽应用于诊断，治疗和/或预防与这些多肽，特别是心血管疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US06700439B2
公开(公告)日：2004-03-02
申请号：US10120750
申请日：2002-04-11
申请人： Donald G. Jackson
发明人： Donald G. Jackson
IPC分类号： H03F102
CPC分类号： H03F1/52 , H03F3/60 , H03F2200/198 , H03F2200/294 , H03F2200/372 , H03F2203/7239
摘要： A zero bypass apparatus for a low noise amplifier includes a bypass circuit, and a switching circuit coupled with a low noise amplifier and with the bypass circuit. The switching circuit includes one or more solid state devices responsive to absence of a control bias for switching an RF input signal from said amplifier to the bypass circuit with a low insertion loss and high isolation.
摘要翻译： 用于低噪声放大器的零旁路装置包括旁路电路和与低噪声放大器和旁路电路耦合的开关电路。 开关电路包括响应于不存在用于以低插入损耗和高隔离将RF输入信号从所述放大器切换到旁路电路的控制偏置的一个或多个固态器件。
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公开(公告)号：US07521044B2
公开(公告)日：2009-04-21
申请号：US11497205
申请日：2006-08-01
CPC分类号： C12N9/16
摘要： The present invention relates to newly discovered human histone deacetylases (HDACs), also referred to as histone deacetylase-like polypeptides. The polynucleotide sequences and encoded polypeptides of the novel HDACs are encompassed by the invention, as well as vectors comprising these polynucleotides and host cells comprising these vectors. The invention also relates to antibodies that bind to the disclosed HDAC polypeptides, and methods employing these antibodies. Also related are methods of screening for modulators, such as inhibitors or antagonists, or agonists. The invention also relates to diagnostic and therapeutic applications which employ the disclosed HDAC polynucleotides, polypeptides, and antibodies, and HDAC modulators. Such applications can be used with diseases and disorders associated with abnormal cell growth or proliferation, cell differentiation, and cell survival, e.g., neoplastic cell growth, and especially breast and prostate cancers or tumors.
摘要翻译： 本发明涉及新发现的人类组蛋白脱乙酰酶（HDAC），也称为组蛋白脱乙酰酶样多肽。 本发明涵盖了新型HDAC的多核苷酸序列和编码多肽，以及包含这些多核苷酸的载体和包含这些载体的宿主细胞。 本发明还涉及结合所公开的HDAC多肽的抗体以及使用这些抗体的方法。 还涉及筛选调节剂的方法，例如抑制剂或拮抗剂或激动剂。 本发明还涉及使用所公开的HDAC多核苷酸，多肽和抗体以及HDAC调节剂的诊断和治疗应用。 这种应用可以用于与异常细胞生长或增殖，细胞分化和细胞存活相关的疾病和病症，例如肿瘤细胞生长，特别是乳腺癌和前列腺癌或肿瘤。
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公开(公告)号：US06701137B1
公开(公告)日：2004-03-02
申请号：US09538955
申请日：2000-03-31
申请人： Mano D. Judd , Gregory A. Maca , Donald G. Jackson
发明人： Mano D. Judd , Gregory A. Maca , Donald G. Jackson
IPC分类号： H04B1500
CPC分类号： H01Q3/28 , H01Q1/246 , H01Q3/26 , H01Q3/2605 , H01Q3/2676 , H01Q21/08 , H01Q23/00
摘要： An antenna system for tower-top installation includes an antenna array of M×N antenna elements, a corporate feed for operatively interconnecting said antenna elements, a backhaul channel for communicating with ground-based equipment, and radio frequency circuits for processing radio frequency signals between the antenna array and a backhaul link. The radio frequency circuits include substantially all of the circuits required for the processing of radio frequency signals between the antenna array and the backhaul link.
摘要翻译： 用于塔顶安装的天线系统包括MxN天线元件的天线阵列，用于可操作地互连所述天线元件的公共馈电，用于与地面设备通信的回程信道，以及用于处理天线之间的射频信号的射频电路 阵列和回程链接。 射频电路基本上包括处理天线阵列和回程链路之间的射频信号所需的所有电路。
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公开(公告)号：US06621469B2
公开(公告)日：2003-09-16
申请号：US09846790
申请日：2001-05-01
IPC分类号： H01Q322
摘要： A distributed antenna device includes a plurality of transmit antenna elements, a plurality of receive antenna elements and a plurality of amplifiers. One of the amplifiers is a power amplifier operatively coupled with each of the transmit antenna elements and mounted closely adjacent to the associated transmit antenna element, such that no appreciable power loss occurs between the power amplifier and the associated antenna element. At least one of the amplifiers is a low noise amplifier and is built into the distributed antenna device for receiving and amplifying signals from at least one of the receive antenna elements. Each power amplifier is a relatively low power, relatively low cost per watt linear amplifier chip.
摘要翻译： 分布式天线装置包括多个发射天线元件，多个接收天线元件和多个放大器。 放大器中的一个是与每个发射天线元件可操作地耦合并且紧密地安装在相关联的发射天线元件上的功率放大器，使得在功率放大器和相关联的天线元件之间不发生明显的功率损耗。 放大器中的至少一个是低噪声放大器，并且内置于分布式天线装置中，用于接收和放大来自至少一个接收天线元件的信号。 每个功率放大器是相对较低的功率，相对低成本的每瓦特线性放大器芯片。
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6.发明申请Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators 审中-公开用于确定对表皮生长因子受体调节剂敏感性的生物标志物和方法公开(公告)号：US20100190150A1
公开(公告)日：2010-07-29
申请号：US10585261
申请日：2005-01-07
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/574 , G01N33/74 , G01N2500/00 , G01N2800/52
摘要： EGFR biomarkers useful in a method for identifying a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises (a) exposing the mammal to the EGFR modulator and (b) measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in (b) compared to the level of the biomarker in a mammal that has not been exposed to the EGFR modulator indicates that the mammal will respond therapeutically to the method of treating cancer.
摘要翻译： EGFR生物标志物可用于鉴定将对治疗癌症治疗的治疗反应的哺乳动物的方法，其包括施用EGFR调节剂，其中所述方法包括（a）将哺乳动物暴露于EGFR调节剂和（b）在哺乳动物中测量水平 的至少一种生物标志物，其中在（b）中测量的至少一种生物标志物水平的差异与尚未暴露于EGFR调节剂的哺乳动物中的生物标志物的水平相比表明哺乳动物将在治疗 涉及治疗癌症的方法。
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公开(公告)号：US07492841B2
公开(公告)日：2009-02-17
申请号：US10354878
申请日：2003-01-30
IPC分类号： H04B7/10
CPC分类号： H04B7/0848 , H04B7/0802 , H04B7/084
摘要： A base station signal is applied to antenna elements. One signal from a first element is electrically modified and evaluated in conjunction with a second, unmodified signal from a second element. The modified signal is further modified and again evaluated with the unmodified signal. The results of the two evaluations are compared to determine a relative phase and/or amplitude at the respective elements.
摘要翻译： 基站信号被施加到天线元件。 来自第一元件的一个信号被电修改并结合来自第二元件的第二未修改信号进行评估。 修改的信号被进一步修改并且再次用未修改的信号进行评估。 比较两个评估的结果以确定各个元件处的相对相位和/或振幅。
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公开(公告)号：US07199227B2
公开(公告)日：2007-04-03
申请号：US10172094
申请日：2002-06-14
申请人： Donald G. Jackson , Matthew V. Lorenzi , Ricardo M. Attar , Marco Gottardis , Liana M. Lee , John N. Feder
发明人： Donald G. Jackson , Matthew V. Lorenzi , Ricardo M. Attar , Marco Gottardis , Liana M. Lee , John N. Feder
IPC分类号： C07H21/04
CPC分类号： C12N9/16
摘要： The present invention relates to newly discovered human histone deacetylases (HDACs), also referred to as histone deacetylase-like polypeptides. The polynucleotide sequences and encoded polypeptides of the novel HDACs are encompassed by the invention, as well as vectors comprising these polynucleotides and host cells comprising these vectors. The invention also relates to antibodies that bind to the disclosed HDAC polypeptides, and methods employing these antibodies. Also related are methods of screening for modulators, such as inhibitors or antagonists, or agonists. The invention also relates to diagnostic and therapeutic applications which employ the disclosed HDAC polynucleotides, polypeptides, and antibodies, and HDAC modulators. Such applications can be used with diseases and disorders associated with abnormal cell growth or proliferation, cell differentiation, and cell survival, e.g., neoplastic cell growth, and especially breast and prostate cancers or tumors.
摘要翻译： 本发明涉及新发现的人类组蛋白脱乙酰酶（HDAC），也称为组蛋白脱乙酰酶样多肽。 本发明涵盖了新型HDAC的多核苷酸序列和编码多肽，以及包含这些多核苷酸的载体和包含这些载体的宿主细胞。 本发明还涉及结合所公开的HDAC多肽的抗体以及使用这些抗体的方法。 还涉及筛选调节剂的方法，例如抑制剂或拮抗剂或激动剂。 本发明还涉及使用所公开的HDAC多核苷酸，多肽和抗体以及HDAC调节剂的诊断和治疗应用。 这种应用可以用于与异常细胞生长或增殖，细胞分化和细胞存活相关的疾病和病症，例如肿瘤细胞生长，特别是乳腺癌和前列腺癌或肿瘤。
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9.发明授权公开(公告)号：US06812786B2
公开(公告)日：2004-11-02
申请号：US10403779
申请日：2003-03-31
IPC分类号： H03F114
CPC分类号： H03F1/52 , H03F3/60 , H03F2200/198 , H03F2200/294 , H03F2200/372 , H03F2203/7239
摘要： A zero-bias bypass apparatus for a low noise amplifier includes a bypass circuit, and a switching circuit coupled with a low noise amplifier and with the bypass circuit. The switching circuit includes one or more solid state devices responsive to absence of a control bias for switching an RF input signal from said amplifier to the bypass circuit with a low insertion loss and high isolation.
摘要翻译： 用于低噪声放大器的零偏置旁路装置包括旁路电路和与低噪声放大器和旁路电路耦合的开关电路。 开关电路包括响应于不存在用于以低插入损耗和高隔离将RF输入信号从所述放大器切换到旁路电路的控制偏置的一个或多个固态器件。
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公开(公告)号：US07811787B2
公开(公告)日：2010-10-12
申请号：US11789322
申请日：2007-04-24
申请人： Donald G. Jackson , Stanley R. Krystek, Jr. , Donna A. Bassolino , Rolf-Peter Ryseck , Thomas C. Nelson , Gena S. Whitney
发明人： Donald G. Jackson , Stanley R. Krystek, Jr. , Donna A. Bassolino , Rolf-Peter Ryseck , Thomas C. Nelson , Gena S. Whitney
CPC分类号： G01N33/6893 , C07K14/47 , G01N33/564 , G01N33/57407 , G01N33/57426 , G01N33/57484 , G01N2800/065 , G01N2800/102 , G01N2800/104 , G01N2800/12 , G01N2800/122 , G01N2800/205 , G01N2800/24 , G01N2800/245
摘要： The invention relates to the identification and cloning of a two novel full-length human SLAP-2 variants and their encoded polypeptides, hSLAP-2v3 and hSLAP-2v4. hSLAP-2v3 and hSLAP-2v4 are members of the SLAP family of adapter proteins and are involved in the negative regulation of intracellular T-cell signal transduction. The invention further relates to the use of these novel hSLAP-2v3 and hSLAP-2v4 polynucleotides and their encoded polypeptides as targets for therapeutic intervention in immunological and inflammatory disorders, autoimmune diseases, pulmonary diseases, proliferative immune disorders, and cancer.
摘要翻译： 本发明涉及两种新型全长人SLAP-2变体及其编码多肽hSLAP-2v3和hSLAP-2v4的鉴定和克隆。 hSLAP-2v3和hSLAP-2v4是SLAP家族接头蛋白的成员，并且参与细胞内T细胞信号转导的负调控。 本发明还涉及这些新型hSLAP-2v3和hSLAP-2v4多核苷酸及其编码多肽作为免疫学和炎症性疾病，自身免疫疾病，肺部疾病，增殖性免疫病症和癌症中的治疗性干预的靶标的用途。
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