发明申请
- 专利标题: BIPHASIC LIPID-VESICLE COMPOSITION AND METHOD FOR TREATING CERVICAL DYSPLASIA BY INTRAVAGINAL DELIVERY
- 专利标题(中): 双向脂肪组合物和通过腹腔内输送治疗宫颈粘液的方法
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申请号: US12532752申请日: 2008-03-27
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公开(公告)号: US20100196453A1公开(公告)日: 2010-08-05
- 发明人: Marianna Foldvari , Praveen Kumar , John M. Docherty
- 申请人: Marianna Foldvari , Praveen Kumar , John M. Docherty
- 国际申请: PCT/CA08/00563 WO 20080327
- 主分类号: A61K38/21
- IPC分类号: A61K38/21 ; A61K9/127 ; A61P15/00
摘要:
A biphasic lipid vesicle composition for treating cervical displasia by intravaginal delivery. The composition includes a suspension of lipid-bilayer vesicles having entrapped therein, an oil-in-water emulsion, human interferon alpha-2b and L-methionine, the composition having an interferon alpha-2b specific activity of between about 1-10 MIU (million international units) per gram composition, and between 0.01 to 0.5 weight percent L-methionine. In the treatment method, the composition is administered at a dose of between about 1-20 MIU interferon alpha-2b, and this dose is administered at least 3 days/week, for a period of at least 4 weeks.
公开/授权文献
- US08945529B2 Biphasic lipid-vesicle compositions 公开/授权日:2015-02-03