Invention Application
- Patent Title: HUMAN MONOCLONAL ANTIBODIES TO ACTIVIN RECEPTOR-LIKE KINASE-1
- Patent Title (中): 人类单克隆抗体活化受体类似激酶-1
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Application No.: US12402854Application Date: 2009-03-12
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Publication No.: US20100197005A1Publication Date: 2010-08-05
- Inventor: Shelley Sims Belouski , Sirid-Aimee Kellermann , Michael Aidan North , Karin Kristina Amundson , Vahe Bedian , Dana Dan Hu-Lowe , Xin Jiang , Shannon Marie Karlicek , James Arthur Thomson , Jianying Wang , Grant Raymond Wickman , Jingchuan Zhang
- Applicant: Shelley Sims Belouski , Sirid-Aimee Kellermann , Michael Aidan North , Karin Kristina Amundson , Vahe Bedian , Dana Dan Hu-Lowe , Xin Jiang , Shannon Marie Karlicek , James Arthur Thomson , Jianying Wang , Grant Raymond Wickman , Jingchuan Zhang
- Applicant Address: US CA Fremont US NY New York
- Assignee: Amgen Fremont Inc.,Pfizer Inc.
- Current Assignee: Amgen Fremont Inc.,Pfizer Inc.
- Current Assignee Address: US CA Fremont US NY New York
- Main IPC: C12N5/10
- IPC: C12N5/10 ; C07H21/04 ; C12N15/74
Abstract:
The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
Public/Granted literature
- US08080646B2 Human monoclonal antibodies to activin receptor-like kinase-1 Public/Granted day:2011-12-20
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