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公开(公告)号：US07537762B2
公开(公告)日：2009-05-26
申请号：US11517530
申请日：2006-09-06
申请人： Michael Aidan North , Karin Kristina Amundson , Vahe Bedian , Shelley Sims Belouski , Dana Dan Hu-Lowe , Xin Jiang , Shannon Marie Karlicek , Sirid Aimee Kellerman , James Arthur Thomson , Jianying Wang , Grant Raymond Wickman , Jingchuan Zhang
发明人： Michael Aidan North , Karin Kristina Amundson , Vahe Bedian , Shelley Sims Belouski , Dana Dan Hu-Lowe , Xin Jiang , Shannon Marie Karlicek , Sirid Aimee Kellerman , James Arthur Thomson , Jianying Wang , Grant Raymond Wickman , Jingchuan Zhang
IPC分类号： A61K39/395 , C07K16/40
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译： 本发明涉及包含结合活化素受体样激酶-1（ALK-1）的细胞外结构域（ECD）的人抗体及其抗原结合部分的抗体，其功能是消除ALK-1 / TGF-β -1 / Smad1信号通路。 本发明还涉及源自人抗ALK-1抗体的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗ALK-1抗体的方法，包含这些抗体的组合物和使用抗体和组合物的方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。
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公开(公告)号：US20100197005A1
公开(公告)日：2010-08-05
申请号：US12402854
申请日：2009-03-12
申请人： Shelley Sims Belouski , Sirid-Aimee Kellermann , Michael Aidan North , Karin Kristina Amundson , Vahe Bedian , Dana Dan Hu-Lowe , Xin Jiang , Shannon Marie Karlicek , James Arthur Thomson , Jianying Wang , Grant Raymond Wickman , Jingchuan Zhang
发明人： Shelley Sims Belouski , Sirid-Aimee Kellermann , Michael Aidan North , Karin Kristina Amundson , Vahe Bedian , Dana Dan Hu-Lowe , Xin Jiang , Shannon Marie Karlicek , James Arthur Thomson , Jianying Wang , Grant Raymond Wickman , Jingchuan Zhang
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译： 本发明涉及包含结合活化素受体样激酶-1（ALK-1）的细胞外结构域（ECD）的人抗体及其抗原结合部分的抗体，其功能是消除ALK-1 / TGF-β -1 / Smad1信号通路。 本发明还涉及源自人抗ALK-1抗体的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗ALK-1抗体的方法，包含这些抗体的组合物和使用抗体和组合物的方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。
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公开(公告)号：US09221915B2
公开(公告)日：2015-12-29
申请号：US13282065
申请日：2011-10-26
申请人： Shelley Sims Belouski , Sirid-Aimée Kellerman , Michael Aidan North , Karin Kristina Amundson , Vahe Bedian , Dana Dan Hu-Lowe , Xin Jiang , Shannon Marie Karlicek , James Arthur Thomson , Jianying Wang , Grant Raymond Wickman , Jingchuan Zhang
发明人： Shelley Sims Belouski , Sirid-Aimée Kellerman , Michael Aidan North , Karin Kristina Amundson , Vahe Bedian , Dana Dan Hu-Lowe , Xin Jiang , Shannon Marie Karlicek , James Arthur Thomson , Jianying Wang , Grant Raymond Wickman , Jingchuan Zhang
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like, kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译： 本发明涉及抗体，其包括结合激活素受体样激酶-1（ALK-1）的细胞外结构域（ECD）的人抗体及其抗原结合部分，其功能是消除ALK-1 / TGF- β-1 / Smad1信号通路。 本发明还涉及源自人抗ALK-1抗体的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗ALK-1抗体的方法，包含这些抗体的组合物和使用抗体和组合物的方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。
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公开(公告)号：US20120052074A1
公开(公告)日：2012-03-01
申请号：US13282065
申请日：2011-10-26
申请人： Shelley Sims Belouski , Sirid-Aimée Kellerman , Michael Aidan North , Karin Kristina Amundson , Vahe Bedian , Dana Dan Hu-Lowe , Xin Jiang , Shannon Marie Karlicek , James Arthur Thomson , Jianying Wang , Grant Raymond Wickman , Jingchuan Zhang
发明人： Shelley Sims Belouski , Sirid-Aimée Kellerman , Michael Aidan North , Karin Kristina Amundson , Vahe Bedian , Dana Dan Hu-Lowe , Xin Jiang , Shannon Marie Karlicek , James Arthur Thomson , Jianying Wang , Grant Raymond Wickman , Jingchuan Zhang
IPC分类号： A61K39/395 , A61P27/02 , A61P17/06 , A61P31/04 , A61P27/06 , A61P29/00 , A61P31/12 , A61P35/00 , A61P19/02
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like, kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译： 本发明涉及抗体，其包括结合激活素受体样激酶-1（ALK-1）的细胞外结构域（ECD）的人抗体及其抗原结合部分，其功能是消除ALK-1 / TGF- β-1 / Smad1信号通路。 本发明还涉及源自人抗ALK-1抗体的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗ALK-1抗体的方法，包含这些抗体的组合物和使用抗体和组合物的方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。
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公开(公告)号：US08080646B2
公开(公告)日：2011-12-20
申请号：US12402854
申请日：2009-03-12
申请人： Michael Aidan North , Karin Kristina Amundson , Vahe Bedian , Shelly Sims Belouski , Dana Dan Hu-Lowe , Xin Jiang , Shannon Marie Karlicek , Sirid Aimee Kellerman , James Arthur Thomson , Jianying Wang , Grant Raymond Wickman , Jingchuan Zhang
发明人： Michael Aidan North , Karin Kristina Amundson , Vahe Bedian , Shelly Sims Belouski , Dana Dan Hu-Lowe , Xin Jiang , Shannon Marie Karlicek , Sirid Aimee Kellerman , James Arthur Thomson , Jianying Wang , Grant Raymond Wickman , Jingchuan Zhang
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译： 本发明涉及包含结合活化素受体样激酶-1（ALK-1）的细胞外结构域（ECD）的人抗体及其抗原结合部分的抗体，其功能是消除ALK-1 / TGF-β -1 / Smad1信号通路。 本发明还涉及源自人抗ALK-1抗体的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗ALK-1抗体的方法，包含这些抗体的组合物和使用抗体和组合物的方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。
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公开(公告)号：US08039596B2
公开(公告)日：2011-10-18
申请号：US12365638
申请日：2009-02-04
申请人： Steven Lee Bender , Gerald Fries Casperson , Dana Dan Hu-Lowe , Xin Jiang , Gang Li , Michael Aidan North , Jianying Wang , Grant Wickman , Peter Brams , Haichun Huang , Brigitte Devaux , Haibin Chen , Dawn M. Tanamachi , Kristopher Toy , Lan Yang , Tim W. Sproul , Mark Yamanaka
发明人： Steven Lee Bender , Gerald Fries Casperson , Dana Dan Hu-Lowe , Xin Jiang , Gang Li , Michael Aidan North , Jianying Wang , Grant Wickman , Peter Brams , Haichun Huang , Brigitte Devaux , Haibin Chen , Dawn M. Tanamachi , Kristopher Toy , Lan Yang , Tim W. Sproul , Mark Yamanaka
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies or antigen binding portions thereof are also provided. The disclosure also provides methods for treating various cancers using the anti-α5β1 antibodies or antigen binding portions thereof described herein.
摘要翻译： 本公开提供以高亲和力特异性结合整联蛋白α5和bgr1的分离的单克隆抗体，特别是人单克隆抗体或其抗原结合部分。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含抗体或其抗原结合部分的药物组合物。 本公开还提供了使用本文所述的抗α5和bgr1抗体或其抗原结合部分治疗各种癌症的方法。
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