Invention Application
US20100209382A1 Polyphenol Conjugates as RGD-Binding Compounds and Methods of Use
审中-公开
多酚缀合物作为RGD结合化合物和使用方法
- Patent Title: Polyphenol Conjugates as RGD-Binding Compounds and Methods of Use
- Patent Title (中): 多酚缀合物作为RGD结合化合物和使用方法
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Application No.: US11992152Application Date: 2006-09-18
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Publication No.: US20100209382A1Publication Date: 2010-08-19
- Inventor: Maria Alexander-Bridges , Shaker A. Mousa , Paul J. Davis
- Applicant: Maria Alexander-Bridges , Shaker A. Mousa , Paul J. Davis
- Applicant Address: US NY Albany
- Assignee: ORDWAY RESEARCH INSTITUTE, INC.
- Current Assignee: ORDWAY RESEARCH INSTITUTE, INC.
- Current Assignee Address: US NY Albany
- International Application: PCT/US2006/036243 WO 20060918
- Main IPC: A61K31/74
- IPC: A61K31/74 ; A61K31/765 ; A61K31/785 ; A61K31/08 ; A61K31/352 ; A61K31/12 ; G01N33/50 ; C12Q1/68 ; C40B30/04 ; G01N33/567 ; A61K31/715 ; A61P3/10
Abstract:
Provided herein are compositions and methods for preventing and treating diseases and risk factors associated with metabolic syndrome by targeting the RGD-binding site of selected intra- and extracellular proteins. Exemplary compositions include RGD-polyphenol conjugates via an ester linkage; polyphenol polymer conjugated to RGD analogs or mimetics; and RGD polymer conjugates linked to polyphenol.
Information query
