发明申请
- 专利标题: TAK1-Mediated Regulation of Osteogenesis
- 专利标题(中): TAK1介导的骨形成调节
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申请号: US12627034申请日: 2009-11-30
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公开(公告)号: US20100209400A1公开(公告)日: 2010-08-19
- 发明人: Dan Gazit , Gadi Pelled , Gadi Turgeman , Andrea Hoffmann , Gerhard Gross , Claas Wodarczyk , Kristin Verschueren
- 申请人: Dan Gazit , Gadi Pelled , Gadi Turgeman , Andrea Hoffmann , Gerhard Gross , Claas Wodarczyk , Kristin Verschueren
- 主分类号: A61K35/12
- IPC分类号: A61K35/12 ; A61K31/7105 ; A61K31/711 ; A61P19/08 ; A61P19/10 ; A61P19/02
摘要:
This invention is directed to methods, nucleic acids and compositions in TAK1-mediated regulation of SMAD activity. Promotion of TAK1 interaction with MH2 domains in SMADs negatively regulates SMAD biological activity. BMP-mediated SMAD activity is subject to TAK1 effects.
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