发明申请
- 专利标题： Methods For The Delivery Of Toxins Or Enzymatically Active Portions Thereof
- 专利标题（中）： 用于递送毒素或其活性部分的方法
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申请号： US12690427申请日： 2010-01-20
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公开(公告)号： US20100209955A1公开(公告)日： 2010-08-19
- 发明人: George A. Oyler , Charles B. Shoemaker , Chuehling Kuo
- 申请人： George A. Oyler , Charles B. Shoemaker , Chuehling Kuo
- 主分类号： C12Q1/37
- IPC分类号： C12Q1/37 ; C12N5/07 ; C12N15/00 ; C12Q1/02
摘要：
The present invention relates to methods, systems, and kits for intoxicating cells, neuronal and non-neuronal cells, with a toxin or fragment thereof. This is done by subjecting toxin substrate and a lipid or polymeric carrier (e.g., DNA uptake facilitating agent) to one or more cells for use in cell based assays. In an aspect, the methods of the present invention allow for high throughput assays and, as such, for the evaluation of drug candidates.