发明申请
- 专利标题： POLYMER CONJUGATES OF GLP-1
- 专利标题（中）： GLP-1的聚合物结合
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申请号： US12086687申请日： 2006-12-18
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公开(公告)号： US20100210505A1公开(公告)日： 2010-08-19
- 发明人: Mary J. Bossard , Zhihao Fang , Tacey X. Viegas , Stewart A. Thompson , Mei-chang Kuo
- 申请人： Mary J. Bossard , Zhihao Fang , Tacey X. Viegas , Stewart A. Thompson , Mei-chang Kuo
- 申请人地址： US AL Huntsville US CA San Carlos
- 专利权人： Nektar Therapeutics AL, Corporation,Nektar Therapeutics
- 当前专利权人： Nektar Therapeutics AL, Corporation,Nektar Therapeutics
- 当前专利权人地址： US AL Huntsville US CA San Carlos
- 国际申请： PCT/US2006/048181 WO 20061218
- 主分类号： A61K38/22
- IPC分类号： A61K38/22 ; C07K14/575 ; A61K38/28 ; A61P3/10
摘要：
Conjugates of a GLP-I moiety may be covalently attached to one or more water-soluble polymers. For instance, a GLP-I polymer conjugate may include a GLP-I moiety releasably attached at its N-terminus to a water-soluble polymer. The GLP-I polymer conjugate may include a GLP-I moiety covalently attached to a water-soluble polymer, wherein the GLP-I moiety possesses an N-methyl substituent. The GLP-I polymer conjugate may include a GLP-I moiety covalently attached at a polymer attachment site to a water-soluble polymer, wherein the GLP-I moiety is glycosylated at a site separate from the polymer attachment site.
公开/授权文献
- US08293869B2 Polymer conjugates of GLP-1 公开/授权日：2012-10-23
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