发明申请
- 专利标题： Combination Therapy for Neuroprotection
- 专利标题（中）： 神经保护联合治疗
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申请号： US12681680申请日： 2008-10-03
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公开(公告)号： US20100216749A1公开(公告)日： 2010-08-26
- 发明人: Sung-Hwa Yoon , Ja-Kyeong Lee , Ho-Joon Park , Young-Gyun Shin , Hae-Un Lee , Seung-Woo Kim , Hyun-Ji Kim
- 申请人： Sung-Hwa Yoon , Ja-Kyeong Lee , Ho-Joon Park , Young-Gyun Shin , Hae-Un Lee , Seung-Woo Kim , Hyun-Ji Kim
- 申请人地址： KR Seoul
- 专利权人： S.H. PHARMA., LTD
- 当前专利权人： S.H. PHARMA., LTD
- 当前专利权人地址： KR Seoul
- 优先权： KR10-2007-0100351 20071005; KR10-2008-0097093 20081002
- 国际申请： PCT/KR08/05841 WO 20081003
- 主分类号： A61K31/616
- IPC分类号： A61K31/616 ; A61K31/138 ; A61P25/00
摘要：
The present invention relates to combination therapy of a pyruvoyl derivative and an anti-oxidant, which is characterized by significant increase of the activity of microglia, inhibition of brain tissue damage by the activation of inflammatory cytokines, improvement of motor skill and recovery effect of neuronal damage. Compared to single treatment with each, this present invention provides a continuous high neuroprotective effect even after 6 hours from the onset of damage.
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