发明申请
- 专利标题: Soluble Guanylate Cyclase Activators
- 专利标题(中): 可溶性鸟苷酸环化酶活化剂
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申请号: US12711854申请日: 2010-02-24
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公开(公告)号: US20100216764A1公开(公告)日: 2010-08-26
- 发明人: Ronald M. Kim , Emma R. Parmee , Christopher Joseph Sinz , Olga A. Ziouzina
- 申请人: Ronald M. Kim , Emma R. Parmee , Christopher Joseph Sinz , Olga A. Ziouzina
- 主分类号: A61K31/397
- IPC分类号: A61K31/397 ; C07D401/14 ; A61K31/4545 ; A61K31/4353 ; C07D487/08 ; A61P9/00 ; A61P11/06 ; A61P3/10
摘要:
This inventions relates to compounds having the structure Formula I and pharmaceutically acceptable salts thereof which are soluble guanylate cyclase activators. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.
公开/授权文献
- US08507512B2 Soluble guanylate cyclase activators 公开/授权日:2013-08-13
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