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公开(公告)号：US08507512B2
公开(公告)日：2013-08-13
申请号：US12711854
申请日：2010-02-24
IPC分类号： A01N43/54 , A01N43/40 , A61K31/505 , A61K31/44 , C07D239/02 , C07D401/00
CPC分类号： C07D401/04 , C07D401/14
摘要： This inventions relates to compounds having the structure Formula I and pharmaceutically acceptable salts thereof which are soluble guanylate cyclase activators. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.
摘要翻译： 本发明涉及具有结构式I的化合物及其可药用盐，它们是可溶性鸟苷酸环化酶活化剂。 该化合物可用于治疗或预防心血管疾病，内皮功能障碍，舒张功能障碍，动脉粥样硬化，高血压，肺动脉高压，心绞痛，血栓形成，再狭窄，心肌梗死，中风，心功能不全，肺性高血压，勃起功能障碍，支气管哮喘，慢性 肾功能不全，糖尿病或肝硬化。
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公开(公告)号：US20100216764A1
公开(公告)日：2010-08-26
申请号：US12711854
申请日：2010-02-24
IPC分类号： A61K31/397 , C07D401/14 , A61K31/4545 , A61K31/4353 , C07D487/08 , A61P9/00 , A61P11/06 , A61P3/10
CPC分类号： C07D401/04 , C07D401/14
摘要： This inventions relates to compounds having the structure Formula I and pharmaceutically acceptable salts thereof which are soluble guanylate cyclase activators. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.
摘要翻译： 本发明涉及具有结构式I的化合物及其可药用盐，它们是可溶性鸟苷酸环化酶活化剂。 该化合物可用于治疗或预防心血管疾病，内皮功能障碍，舒张功能障碍，动脉粥样硬化，高血压，肺动脉高压，心绞痛，血栓形成，再狭窄，心肌梗死，中风，心功能不全，肺性高血压，勃起功能障碍，支气管哮喘，慢性 肾功能不全，糖尿病或肝硬化。
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