Invention Application
US20100216791A1 PYRIDINYLQUINAZOLINAMINE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS
审中-公开
吡啶并噻唑啉衍生物及其作为B-RAF抑制剂的用途
- Patent Title: PYRIDINYLQUINAZOLINAMINE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS
- Patent Title (中): 吡啶并噻唑啉衍生物及其作为B-RAF抑制剂的用途
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Application No.: US12377285Application Date: 2007-08-15
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Publication No.: US20100216791A1Publication Date: 2010-08-26
- Inventor: Brian Aquila , Donald J. Cook , Craig Johnstone , Stephen Lee , Paul Lyne , David Alan Rudge , Melissa Vasbinder , Haixia Wang
- Applicant: Brian Aquila , Donald J. Cook , Craig Johnstone , Stephen Lee , Paul Lyne , David Alan Rudge , Melissa Vasbinder , Haixia Wang
- Applicant Address: SE Södertälje
- Assignee: ASTRAZENECA
- Current Assignee: ASTRAZENECA
- Current Assignee Address: SE Södertälje
- International Application: PCT/GB2007/003111 WO 20070815
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; C07D401/04 ; A61K31/517 ; A61P35/00 ; A61P35/02 ; C07D413/14
Abstract:
The invention relates to chemical compounds of the formula (I) or pharmaceutically acceptable salts thereof, which possess B-Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.
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