发明申请
US20100222413A1 Chemically Modified Oligonucleotides for Use in Modulating Micro RNA and Uses Thereof
有权
用于调节微RNA的化学修饰的寡核苷酸及其用途
- 专利标题： Chemically Modified Oligonucleotides for Use in Modulating Micro RNA and Uses Thereof
- 专利标题（中）： 用于调节微RNA的化学修饰的寡核苷酸及其用途
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申请号： US12714863申请日： 2010-03-01
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公开(公告)号： US20100222413A1公开(公告)日： 2010-09-02
- 发明人: Markus Stoffel , Muthiah Manoharan , Kallanthottathil G. Rajeev
- 申请人： Markus Stoffel , Muthiah Manoharan , Kallanthottathil G. Rajeev
- 申请人地址： US NY New York US MA Cambridge
- 专利权人： The Rockefeller University,Alnylam Pharmaceuticals, Inc.
- 当前专利权人： The Rockefeller University,Alnylam Pharmaceuticals, Inc.
- 当前专利权人地址： US NY New York US MA Cambridge
- 主分类号： A61K31/7088
- IPC分类号： A61K31/7088
摘要：
This invention relates generally to chemically modified oligonuceotides useful for modulating expression of microRNAs and pre-microRNAs. More particularly, the invention relates to single stranded chemically modified oligonuceotides for inhibiting microRNA and pre-microRNA expression and to methods of making and using the modified oligonucleotides. Also included in the invention are compositions and methods for silencing microRNAs in the central nervous system.
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