发明申请
US20100226891A1 SURFACE EXPRESSION VECTOR FOR FUSION PROTEIN OF MYO-2 PEPTIDE MULTIMER AND MYOSTATIN, AND MICROORGANISM TRANSFORMED BY THEREOF
有权
MYO-2肽多糖和肌糖蛋白融合蛋白的表面表达载体及其转化的微生物
- 专利标题： SURFACE EXPRESSION VECTOR FOR FUSION PROTEIN OF MYO-2 PEPTIDE MULTIMER AND MYOSTATIN, AND MICROORGANISM TRANSFORMED BY THEREOF
- 专利标题（中）： MYO-2肽多糖和肌糖蛋白融合蛋白的表面表达载体及其转化的微生物
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申请号： US12682453申请日： 2007-11-30
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公开(公告)号： US20100226891A1公开(公告)日： 2010-09-09
- 发明人: Moon-Hee Sung , Chul Joong Kim , Haryoung Poo , Ji Yeon Kim , Young Suk Kim , Long Chun Xu
- 申请人： Moon-Hee Sung , Chul Joong Kim , Haryoung Poo , Ji Yeon Kim , Young Suk Kim , Long Chun Xu
- 申请人地址： KR Daejeon
- 专利权人： BIOLEADERS CORPORATION
- 当前专利权人： BIOLEADERS CORPORATION
- 当前专利权人地址： KR Daejeon
- 优先权： KR10-2007-0103512 20071015
- 国际申请： PCT/KR07/06147 WO 20071130
- 主分类号： A61K35/74
- IPC分类号： A61K35/74 ; C07K7/08 ; C07K14/00 ; C12N15/74 ; C12N1/21 ; A61K38/16 ; A61P21/00 ; A61P3/00
摘要：
The present invention relates to a fusion protein in which a myostatin mature protein is fused to a multimer of myostatin-derived antigenic peptide Myo-2, a surface expression vector containing a polynucleotide encoding the fusion protein, a recombinant microorganism transformed with the vector, and a feedstuff additive or a pharmaceutical composition containing the microorganism as an effective ingredient. The feedstuff additive or pharmaceutical composition according to the present invention can be used for muscle development and regulation of muscle growth in livestock and poultry, as well as for preventing and treating muscle-wasting diseases and degenerative diseases such as muscular dystrophy, muscular atrophy and the like. In addition, the transformed strain shows the same effect even if the strain itself after culture thereof is directly used, and thus it is very economical.
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