Surface expression vector for fusion protein of Myo-2 peptide multimer and myostatin, and microorganism transformed by thereof
    1.
    发明授权
    Surface expression vector for fusion protein of Myo-2 peptide multimer and myostatin, and microorganism transformed by thereof 有权
    Myo-2肽多聚体和肌生成抑制素融合蛋白的表面表达载体,以及由其转化的微生物

    公开(公告)号:US08470551B2

    公开(公告)日:2013-06-25

    申请号:US12682453

    申请日:2007-11-30

    CPC分类号: C07K14/475

    摘要: The present invention relates to a fusion protein in which a myostatin mature protein is fused to a multimer of myostatin-derived antigenic peptide Myo-2, a surface expression vector containing a polynucleotide encoding the fusion protein, a recombinant microorganism transformed with the vector, and a feedstuff additive or a pharmaceutical composition containing the microorganism as an effective ingredient. The feedstuff additive or pharmaceutical composition according to the present invention can be used for muscle development and regulation of muscle growth in livestock and poultry, as well as for preventing and treating muscle-wasting diseases and degenerative diseases such as muscular dystrophy, muscular atrophy and the like. In addition, the transformed strain shows the same effect even if the strain itself after culture thereof is directly used, and thus it is very economical.

    摘要翻译: 本发明涉及一种融合蛋白,其中肌生成抑制素成熟蛋白质与产生肌生成抑制素的抗原肽Myo-2的多聚体融合,含有编码融合蛋白的多核苷酸的表面表达载体,用载体转化的重组微生物,以及 饲料添加剂或含有该微生物作为有效成分的药物组合物。 根据本发明的饲料添加剂或药物组合物可用于肌肉发育和调节家畜和家禽中的肌肉生长,以及用于预防和治疗肌肉消瘦疾病和退行性疾病如肌营养不良症,肌肉萎缩症和 喜欢。 此外,即使直接使用其培养后的菌株本身,转化菌株也显示相同的效果,因此是非常经济的。

    SURFACE EXPRESSION VECTOR FOR FUSION PROTEIN OF MYO-2 PEPTIDE MULTIMER AND MYOSTATIN, AND MICROORGANISM TRANSFORMED BY THEREOF
    2.
    发明申请
    SURFACE EXPRESSION VECTOR FOR FUSION PROTEIN OF MYO-2 PEPTIDE MULTIMER AND MYOSTATIN, AND MICROORGANISM TRANSFORMED BY THEREOF 有权
    MYO-2肽多糖和肌糖蛋白融合蛋白的表面表达载体及其转化的微生物

    公开(公告)号:US20100226891A1

    公开(公告)日:2010-09-09

    申请号:US12682453

    申请日:2007-11-30

    CPC分类号: C07K14/475

    摘要: The present invention relates to a fusion protein in which a myostatin mature protein is fused to a multimer of myostatin-derived antigenic peptide Myo-2, a surface expression vector containing a polynucleotide encoding the fusion protein, a recombinant microorganism transformed with the vector, and a feedstuff additive or a pharmaceutical composition containing the microorganism as an effective ingredient. The feedstuff additive or pharmaceutical composition according to the present invention can be used for muscle development and regulation of muscle growth in livestock and poultry, as well as for preventing and treating muscle-wasting diseases and degenerative diseases such as muscular dystrophy, muscular atrophy and the like. In addition, the transformed strain shows the same effect even if the strain itself after culture thereof is directly used, and thus it is very economical.

    摘要翻译: 本发明涉及一种融合蛋白,其中肌生成抑制素成熟蛋白质与产生肌生成抑制素的抗原肽Myo-2的多聚体融合,含有编码融合蛋白的多核苷酸的表面表达载体,用载体转化的重组微生物,以及 饲料添加剂或含有该微生物作为有效成分的药物组合物。 根据本发明的饲料添加剂或药物组合物可用于肌肉发育和调节家畜和家禽中的肌肉生长,以及用于预防和治疗肌肉消瘦疾病和退行性疾病如肌营养不良症,肌肉萎缩症和 喜欢。 此外,即使直接使用其培养后的菌株本身,转化菌株也显示相同的效果,因此是非常经济的。

    Constitutive strong promoter and use thereof
    4.
    发明授权
    Constitutive strong promoter and use thereof 有权
    组成型强启动子及其用途

    公开(公告)号:US08236940B2

    公开(公告)日:2012-08-07

    申请号:US12532605

    申请日:2008-03-21

    CPC分类号: C12N15/746 C12N9/1276

    摘要: Disclosed herein are an aldolase gene promoter and the use thereof, more particularly, disclosed are a promoter of aldolase gene derived from Lactobacillus casei, having a base sequence of SEQ ID NO: 1, an expression vector containing said promoter, and a recombinant microorganism transformed with said expression vector. The recombinant microorganism transformed with the expression vector containing the disclosed promoter can effectively express a target protein on the surface thereof, and thus will be useful as vaccine vehicles and the like.

    摘要翻译: 本文公开了醛缩酶基因启动子及其用途,更具体地,公开了源自干酪乳杆菌的醛缩酶基因的启动子,其具有SEQ ID NO:1的碱基序列,含有所述启动子的表达载体和转化的重组微生物 与所述表达载体。 用含有公开的启动子的表达载体转化的重组微生物可以在其表面上有效地表达靶蛋白质,因此可用作疫苗载体等。

    METHOD FOR DIFFERENTIATION INTO RETINAL CELLS FROM STEM CELLS
    6.
    发明申请
    METHOD FOR DIFFERENTIATION INTO RETINAL CELLS FROM STEM CELLS 有权
    从干细胞分化成细胞的方法

    公开(公告)号:US20110223140A1

    公开(公告)日:2011-09-15

    申请号:US13055709

    申请日:2010-10-06

    摘要: Disclosed is a method for inducing stem cells to differentiate into retinal cells at high yield within a short period of time, without gene implantation and co-culture with retinal tissues, by implementing a differentiation process similar to the in vivo embryonic development in chemically defined conditions. Also, retinal cells including the photoreceptor cells and their progenitor cells, and various types of other retinal cells, generated according to the method, are disclosed. A composition comprising the retinal cells and a method are provided for treating retinal degeneration-related diseases. The differentiated photoreceptor cells, when transplanted into degenerated or injured retinas, can be engrafted and fused within the retinas to prevent or cure retinal degeneration.

    摘要翻译: 公开了一种诱导干细胞在短时间内以高产率分化成视网膜细胞的方法,通过实施类似于在化学定义的条件下的体内胚胎发育的分化过程,而不进行基因植入和与视网膜组织的共培养 。 此外,还公开了根据该方法产生的包括感光细胞及其祖细胞的视网膜细胞和各种类型的其它视网膜细胞。 提供了包含视网膜细胞的组合物和一种治疗视网膜变性相关疾病的方法。 分化的感光细胞,当移植到退化或损伤的视网膜时,可以植入并融合在视网膜内,以预防或治愈视网膜变性。

    METHOD OF CHECKING MODIFICATION OF TRANSMITTED MESSAGE IN MOBILE COMMUNICATION TERMINAL AND MOBILE COMMUNICATION TERMINAL PERFORMING THE SAME
    7.
    发明申请
    METHOD OF CHECKING MODIFICATION OF TRANSMITTED MESSAGE IN MOBILE COMMUNICATION TERMINAL AND MOBILE COMMUNICATION TERMINAL PERFORMING THE SAME 有权
    检查移动通信终端和移动通信终端中发送的消息的修改方法

    公开(公告)号:US20080076457A1

    公开(公告)日:2008-03-27

    申请号:US11856553

    申请日:2007-09-17

    申请人: Ji Yeon Kim

    发明人: Ji Yeon Kim

    IPC分类号: H04Q7/20

    CPC分类号: H04W4/12 H04W4/18 H04W88/184

    摘要: A method of checking for modification of a message transmitted by a transmitting mobile terminal comprises transmitting an original message to a receiving mobile terminal, receiving a report message comprising information about any modification of the original message, and displaying information about the modification of the original message.

    摘要翻译: 一种检查由发送移动终端发送的消息的修改的方法包括:向接收移动终端发送原始消息,接收包括关于原始消息的任何修改的信息的报告消息,以及显示关于原始消息的修改的信息 。