发明申请
- 专利标题: HYDRAZIDE DERIVATIVES
- 专利标题(中): 氢化衍生物
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申请号: US12791571申请日: 2010-06-01
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公开(公告)号: US20100240654A1公开(公告)日: 2010-09-23
- 发明人: Richard CLARK , Shinsuke HIROTA , Hiroshi AZUMA , Kazunobu KIRA , Nobuhisa WATANABE , Tadashi NAGAKURA , Tatsuo HORIZOE
- 申请人: Richard CLARK , Shinsuke HIROTA , Hiroshi AZUMA , Kazunobu KIRA , Nobuhisa WATANABE , Tadashi NAGAKURA , Tatsuo HORIZOE
- 优先权: JPP2004-298379 20041013
- 主分类号: A61K31/5377
- IPC分类号: A61K31/5377 ; C07C243/22 ; A61K31/15 ; C07D211/72 ; A61K31/4402 ; C07D215/38 ; A61K31/47 ; C07D239/32 ; C07D295/28 ; A61K31/5375 ; C07D413/04 ; A61P7/02 ; A61P9/10 ; A61P9/00 ; A61P7/00
摘要:
A compound represented by the following general formula (1) or a salt thereof or a hydrate of the foregoing is safe while exhibiting suitable physicochemical stability, and is useful as therapeutic or prophylactic agents for diseases associated with thrombus formation. wherein R1a, R1b, R1c and R1d each independently represent hydrogen, etc., R2 represents optionally substituted phenyl, etc., R3 represents optionally substituted C6-10 aryl, etc., Z1, Z2 and Z3 each independently represent hydrogen, etc., Z4 represents hydrogen, etc. and X represents a single bond or —CO—, etc.