发明申请
- 专利标题: OXYIMINO COMPOUNDS AND THE USE THEREOF
- 专利标题(中): OXYIMINO化合物及其用途
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申请号: US12602441申请日: 2008-05-30
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公开(公告)号: US20100240703A1公开(公告)日: 2010-09-23
- 发明人: Moriyasu Masui , Hidenori Mikamiyama , Naoki Tsuno
- 申请人: Moriyasu Masui , Hidenori Mikamiyama , Naoki Tsuno
- 国际申请: PCT/US08/06888 WO 20080530
- 主分类号: A61K31/445
- IPC分类号: A61K31/445 ; C07D211/96 ; A61P29/00 ; A61P25/00 ; A61P9/06 ; A61P9/12 ; G01N33/53
摘要:
The invention relates to oxyimino compounds of (Formula I), and pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein: Y is CO or SOm; Z is hydrogen, each optionally substituted lower alkyl, lower alkenyl, aryl, heterocyclyl etc. R1 and R2 are each independently hydrogen, each optionally substituted lower alkyl, lower alkenyl, cycloalkyl, aryl, heterocyclyl etc., each X is independently ═O, optionally substituted lower alkyl, cyano, nitro etc., m is 1 or 2, p is O, 1 or 2 and q is O or 1. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
公开/授权文献
- US08563732B2 Oxyimino compounds and the use thereof 公开/授权日:2013-10-22