发明申请
- 专利标题： PIRENZEPINE AND DERIVATIVES THEREOF AS ANTI-AMYLOID AGENTS
- 专利标题（中）： 哌嗪及其衍生物作为抗淀粉剂
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申请号： US12667445申请日： 2008-07-02
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公开(公告)号： US20100247688A1公开(公告)日： 2010-09-30
- 发明人: Andrea Pfeifer , André Schrattenholz , Andreas Muhs
- 申请人： Andrea Pfeifer , André Schrattenholz , Andreas Muhs
- 优先权： EP07111491.2 20070702
- 国际申请： PCT/EP08/58527 WO 20080702
- 主分类号： A61K36/16
- IPC分类号： A61K36/16 ; C07D487/14 ; A61K31/5513 ; A61K38/17 ; A61K31/55 ; A61K31/714 ; A61K31/685 ; A61P25/00 ; A61P25/28 ; A61P31/18 ; A61P27/02 ; A61P9/00 ; A61P5/00 ; A61P3/10
摘要：
The present invention relates to a compound that is capable of inhibiting the formation of β-amyloid plaques, of reducing and/or retarding the increase the β-amyloid plaque load in the brain of an animal, particularly a mammal, but especially a human. In particular, the invention relates to compounds of formula (I) and to metabolites thereof.
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