发明申请
- 专利标题: PEPTIDES, COMPOSITIONS AND USES THEREOF
- 专利标题(中): 肽,组合物及其用途
-
申请号: US12449950申请日: 2008-03-07
-
公开(公告)号: US20100249035A1公开(公告)日: 2010-09-30
- 发明人: Christopher Shaw , Tianbao Chen , Martin O'Rourke , Brian Walker , David Hirst
- 申请人: Christopher Shaw , Tianbao Chen , Martin O'Rourke , Brian Walker , David Hirst
- 申请人地址: GB Belfast
- 专利权人: The Queen's University of Belfast
- 当前专利权人: The Queen's University of Belfast
- 当前专利权人地址: GB Belfast
- 优先权: GB0704352.4 20070307
- 国际申请: PCT/GB2008/050163 WO 20080307
- 主分类号: A61K38/08
- IPC分类号: A61K38/08 ; C07H21/04 ; A61P9/00 ; A61P17/00 ; A61K31/7088 ; C07K7/06
摘要:
Described is an N-terminal hexapeptide fragment of maximakinin, QUB 698.8, which exhibits potent tissue selective actions on smooth muscle. It demonstrates a high degree of selectivity for arterial smooth muscle over small intestinal smooth muscle, causing potent relaxation of arterial smooth muscle, while causing less potent contraction of ileal smooth muscle. It may be used treatment of diseases of the cardiovascular system and in promotion of angiogenesis.
公开/授权文献
- US08217011B2 Peptides, compositions and uses thereof 公开/授权日:2012-07-10