发明申请
- 专利标题: MEASUREMENT OF NEURAL FUNCTIONALITY USING PHASE SENSITIVE OPTICAL COHERENCE REFLECTOMETRY
- 专利标题(中): 使用相敏感光学相干反射测量法测量神经功能
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申请号: US12717735申请日: 2010-03-04
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公开(公告)号: US20100249609A1公开(公告)日: 2010-09-30
- 发明人: Taner AKKIN , Thomas E. Milner , Digant P. Dave , H. Grady Rylander
- 申请人: Taner AKKIN , Thomas E. Milner , Digant P. Dave , H. Grady Rylander
- 申请人地址: US TX Austin
- 专利权人: Board of Regents, the University of Texas System
- 当前专利权人: Board of Regents, the University of Texas System
- 当前专利权人地址: US TX Austin
- 主分类号: A61B6/00
- IPC分类号: A61B6/00
摘要:
Optical methods, devices, and systems for noninvasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflect ion coatings are not required. Transient neural surface displacement of less then 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.