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1.发明申请公开(公告)号：US20200040385A1
公开(公告)日：2020-02-06
申请号：US16596596
申请日：2019-10-08
发明人： Joseph M. BEECHEM , Charles WARREN , Chris MERRITT , Jaemyeong JUNG , Dwayne L. DUNAWAY , Scott CROWDER , Kristina SORG , Gordon B. MILLS
IPC分类号： C12Q1/6841 , C12Q1/6823 , G01N33/68
摘要： The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.
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公开(公告)号：US20240360604A1
公开(公告)日：2024-10-31
申请号：US18769833
申请日：2024-07-11
发明人： Janeta Zoldan , Alicia Allen
IPC分类号： D04H1/4334 , C12N5/00 , C12N5/077 , C12N5/079 , D04H1/43 , D04H1/4382 , D04H1/728 , D04H13/00
CPC分类号： D04H1/4334 , C12N5/0068 , C12N5/0618 , C12N5/0654 , C12N5/0655 , C12N5/0657 , C12N5/0658 , D04H1/43 , D04H1/43828 , D04H1/43835 , D04H1/43838 , D04H1/728 , C12N2533/30 , C12N2539/10 , D04H13/002
摘要： The present invention provides compositions comprising aligned fibers of electrospun PNIPAAm and poly (ε-caprolactone) (PCL) (denoted PNIPAAm/PCL fibers). The PNIPAAm/PCL compositions enable enhanced growth and detachment of intact anisotropic cell sheets. The compositions do not require chemical modification or resource-intensive techniques, thus saving time and expense, and have the potential to generate tissue-specific, aligned cell sheets for transplant studies.
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公开(公告)号：US20240350543A1
公开(公告)日：2024-10-24
申请号：US18638229
申请日：2024-04-17
发明人： Katy Rezvani , Rafet Basar , Paul Lin , Michael David Curley , LeeAnn Talarico , Prashanth Vishwanath , James Wilson Meador, III
IPC分类号： A61K35/17 , A61K9/00 , A61K39/00 , A61P35/00 , C07K14/54 , C07K14/705 , C07K14/725 , C07K16/28 , C12N15/85
CPC分类号： A61K35/17 , A61K9/0019 , A61K39/4611 , A61K39/4613 , A61K39/464417 , A61P35/00 , C07K14/5443 , C07K14/7051 , C07K14/70521 , C07K16/2878 , C12N15/85 , A61K2239/13 , A61K2239/21 , A61K2239/22 , C07K2317/53 , C07K2317/565 , C07K2317/622
摘要： The present application provides BCMA targeting chimeric antigen receptor (CAR) comprising a BCMA binding region and an intracellular costimulatory domain derived from DAP10. Further provided are engineered immune effector cells (such as NK cells) comprising the chimeric antigen receptors. Pharmaceutical compositions, kits and methods of treating cancer are also provided.
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公开(公告)号：US12121216B2
公开(公告)日：2024-10-22
申请号：US17670730
申请日：2022-02-14
发明人： Baowei Fei , Naeeme Modir
CPC分类号： A61B1/045 , A61B1/00016 , A61B1/0655 , A61B1/0684 , G01J3/2823 , G01J2003/2826
摘要： A miniaturized device providing hyperspectral imaging in real-time includes a body, a camera within the body, a micro-LED array arranged around the camera within the body, and an imaging controller within the body and coupled to the camera and the micro-LED array. The micro-LED array includes micro-LEDs of varying spectral bands. A method for controlling an imaging device includes providing LED timing information and LED intensity information to a micro-LED array, providing camera timing information to a camera for capturing a plurality of images, and receiving the plurality of images from the camera. The timing information includes a timing signal to each micro-LED of the micro-LED array and each timing signal includes a pulse. An image of the plurality of images is captured for a time period associated with each timing signal.
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5.发明公开公开(公告)号：US20240348228A1
公开(公告)日：2024-10-17
申请号：US18631914
申请日：2024-04-10
申请人： The Board of Trustees of the Leland Stanford Junior University , Board of Regents, The University of Texas System
发明人： Eric Stolt , Juan Rivas-Davila , Weston Braun , Ruochen Lu , Kristi Nguyen
IPC分类号： H03H9/02 , H03H9/17 , H10N30/853
CPC分类号： H03H9/02086 , H03H9/17 , H10N30/8542
摘要： In certain examples, methods and apparatus are directed to a resonator-based circuit which, in operation, has an electrically-conductive band (“band”) at least partially surrounding a center electrode which includes the piezoelectric material of the circuit's resonator. In particular examples, the band acts to electrically load vibrations near resonance and consequently, spurious mode suppression is realized. In more particular example embodiments, the band maintains TE mode while eliminating lateral spurious tones, and in one application-specific example, the resonator-based circuitry and the electrical-conductive band are to provide of facilitate piezoelectric power conversion.
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公开(公告)号：US20240342091A1
公开(公告)日：2024-10-17
申请号：US18634454
申请日：2024-04-12
CPC分类号： A61K9/1682 , A61K9/1658 , B01D9/005 , Y10T428/2982
摘要： The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm−1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30° C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm−1.
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公开(公告)号：US20240341775A1
公开(公告)日：2024-10-17
申请号：US18681266
申请日：2022-08-19
发明人： Farshid Alambeigi , Yang Liu
CPC分类号： A61B17/1631 , A61B17/1615 , A61B17/1626 , A61B17/1628 , A61B34/10 , A61B34/30 , A61B2034/105
摘要： A fully steerable flexible curved drilling robot device comprises a first flexible tube including a concentric through hole centered on a longitudinal axis, a second flexible tube including an eccentric through hole, wherein the second flexible tube is positioned in the concentric though hole of the first flexible tube, and configured to move translationally along the longitudinal axis and rotationally about the longitudinal axis, and a drill bit connected via a bearing to a flexible drive shaft, the drill bit positioned at a distal end of the first flexible tube, and wherein the flexible drive shaft extends through the eccentric through hole of the second flexible tube and is configured to provide a rotational torque to the drill bit. A steerable flexible curved drilling robot system and drilling method are also disclosed.
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公开(公告)号：US20240339654A1
公开(公告)日：2024-10-10
申请号：US18287393
申请日：2022-04-18
发明人： John B. GOODENOUGH , Yutao LI , Biyi XU
IPC分类号： H01M10/056
CPC分类号： H01M10/056 , H01M2300/0071 , H01M2300/0082 , H01M2300/0091
摘要： Disclosed is a solid-state ion-conducting composite electrolyte comprising: a) a polymer host; b) an alkali metal salt comprising a monovalent metal cation, wherein the alkali metal salt is dispersed in the polymer host; and c) a functional additive comprising at least one divalent and/or trivalent metal cation; wherein an ionic radius of the at least one divalent and/or trivalent metal cation of the functional additive is substantially similar to an ionic radius of the monovalent metal cation of the alkali metal salt; and wherein the functional additive is substantially dissolved within the polymer host; and wherein the solid-state ion-conducting composite electrolyte has an ionic conductivity of at least about 10−4 S/cm at room temperature.
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9.发明公开公开(公告)号：US20240336900A1
公开(公告)日：2024-10-10
申请号：US18436635
申请日：2024-02-08
发明人： Andrew Ellington , Simon d’Oelsnitz , Daniel Diaz
CPC分类号： C12N9/1007 , C12P17/18 , G16B15/00 , G16B40/20
摘要： This invention relates to non-naturally occurring methyltransferase, wherein said methyltransferase can methylate norbelladine to form 4-O'Methylnorbelladine. The invention is also drawn to a biosensor for detecting 4-O'Methylnorbelladine, wherein the biosensor comprises an engineered substrate-promiscuous regulator, wherein said substrate-promiscuous regulator has been engineered to interact more efficiently with 4-O'Methylnorbelladine than does a naturally occurring substrate promiscuous regulator; and further wherein the biosensor is engineered to provide an output signal, wherein said output signal is generated when the biosensor interacts with 4-O'Methylnorbelladine.
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公开(公告)号：US20240335574A1
公开(公告)日：2024-10-10
申请号：US18294090
申请日：2022-08-02
发明人： Ryan Bitar , William Phillips
CPC分类号： A61K51/1265 , A61K41/00 , A61K49/0091 , A61K49/0438
摘要： Certain embodiments are directed to Lipid Emulsions in Alginate Microspheres, e.g., Lipiodol Emulsion in Alginate Microspheres (LEAMs), as a chemoembolic agent. A oil in water emulsion of lipiodol can be stabilized within alginate microspheres at very high concentrations. These emulsion in alginate microspheres can be manufactured to any size range from 20 microns to 5000 microns. In certain aspects, an ultrasonic nozzle technology is used to manufacture small size microspheres of average diameter 50 microns. In other aspects, needle extrusion systems are used to manufacture large LEAMs termed Mega-LEAMs.
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