发明申请
US20100254983A1 USES OF RAGE ANTAGONISTS FOR TREATING OBESITY AND RELATED DISEASES
审中-公开
用于治疗肥胖和相关疾病的RAGE ANTAGONISTS的用途
- 专利标题： USES OF RAGE ANTAGONISTS FOR TREATING OBESITY AND RELATED DISEASES
- 专利标题（中）： 用于治疗肥胖和相关疾病的RAGE ANTAGONISTS的用途
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申请号： US12451894申请日： 2008-06-06
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公开(公告)号： US20100254983A1公开(公告)日： 2010-10-07
- 发明人: Ann Marie Schmidt , Anthony Ferrante , Fei Song
- 申请人： Ann Marie Schmidt , Anthony Ferrante , Fei Song
- 国际申请： PCT/US2008/007143 WO 20080606
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K38/16 ; A61K31/415 ; A61K31/695 ; A61P3/06 ; A61P3/04 ; A61P3/10
摘要：
This invention provides a method for treating obesity in which comprises administering to the subject an antagonist of a receptor for advanced glycation end products (RAGE) in an amount effective to inhibit binding of a ligand of RAGE to RAGE so as to thereby treat obesity in the subject. The present invention also provides a method for treating hyperglycemia and increased cholesterol, insulin, triglyceride and leptin levels comprising administering to the subject an antagonist of RAGE in an amount effective to inhibit binding of a ligand of RAGE to RAGE so as to thereby treat hyperglycemia and lower cholesterol, insulin, triglyceride and leptin levels on the subject.
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