发明申请
US20100256222A1 MICRO-RNA SCAFFOLDS, NON-NATURALLY OCCURRING MICRO-RNAS, AND METHODS FOR OPTIMIZING NON-NATURALLY OCCURRING MICRO-RNAS
有权
MICRO-RNA SCAFFOLDS，Non-NATURALLY OCCURRING MICRO-RNAS，和METHODS FOR OPTIMIZING NANNA NATURALLY OCCURRING MICRO-RNAS
- 专利标题： MICRO-RNA SCAFFOLDS, NON-NATURALLY OCCURRING MICRO-RNAS, AND METHODS FOR OPTIMIZING NON-NATURALLY OCCURRING MICRO-RNAS
- 专利标题（中）： MICRO-RNA SCAFFOLDS，Non-NATURALLY OCCURRING MICRO-RNAS，和METHODS FOR OPTIMIZING NANNA NATURALLY OCCURRING MICRO-RNAS
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申请号： US12601506申请日： 2008-05-22
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公开(公告)号： US20100256222A1公开(公告)日： 2010-10-07
- 发明人: Melissa Kelley , Amanda Birmingham , Jon Karpilow , Anastasia Khvorova , Kevin Sullivan
- 申请人： Melissa Kelley , Amanda Birmingham , Jon Karpilow , Anastasia Khvorova , Kevin Sullivan
- 申请人地址： US CO Lafayette
- 专利权人： DHARMACON, INC.
- 当前专利权人： DHARMACON, INC.
- 当前专利权人地址： US CO Lafayette
- 国际申请： PCT/US2008/064458 WO 20080522
- 主分类号： A61K31/7088
- IPC分类号： A61K31/7088 ; C07H21/02 ; C12N15/63 ; C12N5/10 ; C12Q1/68
摘要：
The present disclosure provides non-naturally occurring miR-196a-2 miRNAs and non-naturally occurring miR-204 miRNAs. The non-naturally occurring miRNAs of the disclosure have mature strand sequences distinct from their endogenous counterparts. The disclosure also provides methods of selecting mature strand sequences that function optimally in non-naturally occurring miR-196a-2 miRNAs. The methods and compositions of the disclosure may be used to mediate gene silencing via the RNAi pathway.
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