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1.发明授权Micro-RNA scaffolds, non-naturally occurring micro-RNAs, and methods for optimizing non-naturally occurring micro-RNAs 有权微RNA支架，非天然存在的微RNA，以及优化非天然存在的微RNA的方法公开(公告)号：US08841267B2
公开(公告)日：2014-09-23
申请号：US12601506
申请日：2008-05-22
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/141 , C12N2310/531 , C12N2320/30 , C12N2330/30 , C12Q1/6869
摘要： The present disclosure provides non-naturally occurring miR-196a-2 miRNAs and non-naturally occurring miR-204 miRNAs. The non-naturally occurring miRNAs of the disclosure have mature strand sequences distinct from their endogenous counterparts. The disclosure also provides methods of selecting mature strand sequences that function optimally in non-naturally occurring miR-196a-2 miRNAs. The methods and compositions of the disclosure may be used to mediate gene silencing via the RNAi pathway.
摘要翻译： 本公开提供非天然存在的miR-196a-2 miRNA和非天然存在的miR-204 miRNA。 本公开的非天然存在的miRNA具有与其内源对应物不同的成熟链序列。 本公开还提供了选择在非天然存在的miR-196a-2 miRNA中最佳起作用的成熟链序列的方法。 本公开的方法和组合物可用于通过RNAi途径介导基因沉默。
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公开(公告)号：US09353368B2
公开(公告)日：2016-05-31
申请号：US12601508
申请日：2008-05-22
IPC分类号： C12N15/11 , C07H21/04 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/141 , C12N2310/531 , C12N2320/30 , C12N2330/30 , C12Q1/6869
摘要： The present disclosure provides a non-naturally occurring miRNA having a stem-loop structure comprising a scaffold derived from a first endogenous miRNA (e.g., miR-196a-2 or miR-204), a mature strand derived from a second endogenous miRNA, and a star strand sequence that is at least partially complementary to the mature strand sequence. The present disclosure also provides a non-naturally occurring miRNA having a stem-loop structure comprising a scaffold derived from an endogenous miRNA (e.g., miR-196a-2 or miR-204), a mature strand designed t be at least partially complementary to a target RNA, and a star strand sequence that is at least partially complementary to the mature strand sequence. The methods and compositions of the disclosure may be used to mediate gene silencing via the RNAi pathway.
摘要翻译： 本公开提供了非天然存在的具有茎环结构的miRNA，其包含源自第一内源miRNA（例如，miR-196a-2或miR-204）的支架，源自第二内源miRNA的成熟链，以及 与成熟链序列至少部分互补的星形链序列。 本公开还提供了非天然存在的miRNA，其具有包含源自内源miRNA（例如，miR-196a-2或miR-204）的支架的茎环结构，成熟链被设计为至少部分地与 靶RNA和与成熟链序列至少部分互补的星形链序列。 本公开的方法和组合物可用于通过RNAi途径介导基因沉默。
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3.发明申请MICRO-RNA SCAFFOLDS, NON-NATURALLY OCCURRING MICRO-RNAS, AND METHODS FOR OPTIMIZING NON-NATURALLY OCCURRING MICRO-RNAS 有权MICRO-RNA SCAFFOLDS，Non-NATURALLY OCCURRING MICRO-RNAS，和METHODS FOR OPTIMIZING NANNA NATURALLY OCCURRING MICRO-RNAS公开(公告)号：US20100256222A1
公开(公告)日：2010-10-07
申请号：US12601506
申请日：2008-05-22
IPC分类号： A61K31/7088 , C07H21/02 , C12N15/63 , C12N5/10 , C12Q1/68
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/141 , C12N2310/531 , C12N2320/30 , C12N2330/30 , C12Q1/6869
摘要： The present disclosure provides non-naturally occurring miR-196a-2 miRNAs and non-naturally occurring miR-204 miRNAs. The non-naturally occurring miRNAs of the disclosure have mature strand sequences distinct from their endogenous counterparts. The disclosure also provides methods of selecting mature strand sequences that function optimally in non-naturally occurring miR-196a-2 miRNAs. The methods and compositions of the disclosure may be used to mediate gene silencing via the RNAi pathway.
摘要翻译： 本公开提供非天然存在的miR-196a-2 miRNA和非天然存在的miR-204 miRNA。 本公开的非天然存在的miRNA具有与其内源对应物不同的成熟链序列。 本公开还提供了选择在非天然存在的miR-196a-2 miRNA中最佳起作用的成熟链序列的方法。 本公开的方法和组合物可用于通过RNAi途径介导基因沉默。
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4.发明申请公开(公告)号：US20100292310A1
公开(公告)日：2010-11-18
申请号：US12601508
申请日：2008-05-22
IPC分类号： A61K31/7088 , C07H21/02 , C12N15/63 , C12N5/10
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/141 , C12N2310/531 , C12N2320/30 , C12N2330/30 , C12Q1/6869
摘要： The present disclosure provides a non-naturally occurring miRNA having a stem-loop structure comprising a scaffold derived from a first endogenous miRNA (e.g., miR-196a-2 or miR-204), a mature strand derived from a second endogenous miRNA, and a star strand sequence that is at least partially complementary to the mature strand sequence. The present disclosure also provides a non-naturally occurring miRNA having a stem-loop structure comprising a scaffold derived from an endogenous miRNA (e.g., miR-196a-2 or miR-204), a mature strand designed t be at least partially complementary to a target RNA, and a star strand sequence that is at least partially complementary to the mature strand sequence. The methods and compositions of the disclosure may be used to mediate gene silencing via the RNAi pathway.
摘要翻译： 本公开提供了非天然存在的具有茎环结构的miRNA，其包含源自第一内源miRNA（例如，miR-196a-2或miR-204）的支架，源自第二内源miRNA的成熟链，以及 与成熟链序列至少部分互补的星形链序列。 本公开还提供了非天然存在的miRNA，其具有包含源自内源miRNA（例如，miR-196a-2或miR-204）的支架的茎环结构，成熟链被设计为至少部分地与 靶RNA和与成熟链序列至少部分互补的星形链序列。 本公开的方法和组合物可用于通过RNAi途径介导基因沉默。
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