发明申请
- 专利标题： EXO-SELECTIVE SYNTHESIS OF HIMBACINE ANALOGS
- 专利标题（中）： 苯菌胺类似物的选择性合成
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申请号： US12827000申请日： 2010-06-30
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公开(公告)号： US20100267947A1公开(公告)日： 2010-10-21
- 发明人: Tiruvettipuram K. Thiruvengadam , Anantha R. Sudhakar , Ngiap Kie Lim , Daw-long Kwok , George G. Wu , Tao Wang , Mingsheng Huang , Michael D. Green
- 申请人： Tiruvettipuram K. Thiruvengadam , Anantha R. Sudhakar , Ngiap Kie Lim , Daw-long Kwok , George G. Wu , Tao Wang , Mingsheng Huang , Michael D. Green
- 申请人地址： US NJ Kenilworth
- 专利权人： SCHERING CORPORATION
- 当前专利权人： SCHERING CORPORATION
- 当前专利权人地址： US NJ Kenilworth
- 主分类号： C07D413/12
- IPC分类号： C07D413/12 ; C07D317/72 ; C07C269/06 ; C07D307/92 ; C07D405/08
摘要：
This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence:
公开/授权文献
- US08138180B2 Exo-selective synthesis of himbacine analogs 公开/授权日：2012-03-20
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