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发明申请
US20100273808A1 LACTATE SALT OF 4-[6-METHOXY-7-(3-PIPERIDIN-1-YL-PROPOXY)QUINAZOLIN-4-YL]PIPERAZINE-1-CARBOXYLIC ACID(4-ISOPROPOXYPHENYL)-AMIDE AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CANCER AND OTHER DISEASES OR DISORDERS 审中-公开
4- [6-甲氧基-7-（3-哌啶-1-基 - 丙氧基）喹唑啉-4-基]哌嗪-1-羧酸（4-异丙氧基） - 酰胺及其药物组合物的盐酸盐 癌症及其他疾病或病症

LACTATE SALT OF 4-[6-METHOXY-7-(3-PIPERIDIN-1-YL-PROPOXY)QUINAZOLIN-4-YL]PIPERAZINE-1-CARBOXYLIC ACID(4-ISOPROPOXYPHENYL)-AMIDE AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CANCER AND OTHER DISEASES OR DISORDERS
摘要：
This invention provides a compound of formula (I): or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof; processes for the synthesis or manufacture of the compound of formula (I), or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof; and the use of said compound, or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof, for the treatment of patients suffering from or subject to diseases, disorders or conditions involving cell survival, proliferation, and migration, including cardiovascular disease (e.g., arteriosclerosis and vascular reobstruction), cancer, (e.g., AML and malignant glioma)glomerulosclerosis, fibrotic disease and inflammation.
摘要（中）：

本发明提供式（I）化合物或其结晶形式，或其药物组合物，或其口服药物剂型; 用于合成或制备式（I）化合物或其结晶形式或其药物组合物或其口服药物剂型的方法; 以及使用所述化合物或其结晶形式或其药物组合物或其口服药物剂型用于治疗患有或患有涉及细胞存活，增殖和迁移的疾病，病症或病症的患者 包括心血管疾病（如动脉硬化和血管重构），癌症（如AML和恶性胶质瘤）肾小球硬化，纤维化疾病和炎症。

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