公开(公告)号：US20100273808A1

公开(公告)日：2010-10-28

申请号：US12622617

申请日：2009-11-20

申请人： Ian Armitage ,  Michael E. Bourland ,  Craig J.S. Boyle ,  Martin Ian Cooper ,  Abu J. Ferdous ,  Marianne Langston

发明人： Ian Armitage ,  Michael E. Bourland ,  Craig J.S. Boyle ,  Martin Ian Cooper ,  Abu J. Ferdous ,  Marianne Langston

IPC分类号： A61K31/496 ,  C07D401/14 ,  A61P35/00 ,  A61P35/02 ,  B05D3/00

CPC分类号： A61K31/517 ,  C07D239/94

摘要： This invention provides a compound of formula (I): or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof; processes for the synthesis or manufacture of the compound of formula (I), or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof; and the use of said compound, or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof, for the treatment of patients suffering from or subject to diseases, disorders or conditions involving cell survival, proliferation, and migration, including cardiovascular disease (e.g., arteriosclerosis and vascular reobstruction), cancer, (e.g., AML and malignant glioma)glomerulosclerosis, fibrotic disease and inflammation.

摘要翻译： 本发明提供式（I）化合物或其结晶形式，或其药物组合物，或其口服药物剂型; 用于合成或制备式（I）化合物或其结晶形式或其药物组合物或其口服药物剂型的方法; 以及使用所述化合物或其结晶形式或其药物组合物或其口服药物剂型用于治疗患有或患有涉及细胞存活，增殖和迁移的疾病，病症或病症的患者 包括心血管疾病（如动脉硬化和血管重构），癌症（如AML和恶性胶质瘤）肾小球硬化，纤维化疾病和炎症。