发明申请
US20100285023A1 DETECTING CYP24 EXPRESSION LEVEL AS A MARKER FOR PREDISPOSITION TO CANCER
有权
检测CYP24表达水平作为癌症预测标记
- 专利标题: DETECTING CYP24 EXPRESSION LEVEL AS A MARKER FOR PREDISPOSITION TO CANCER
- 专利标题(中): 检测CYP24表达水平作为癌症预测标记
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申请号: US12633643申请日: 2009-12-08
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公开(公告)号: US20100285023A1公开(公告)日: 2010-11-11
- 发明人: Donna G. Albertson , Daniel Pinkel , Colin Collins , Joe W. Gray , Bauke Ylstra
- 申请人: Donna G. Albertson , Daniel Pinkel , Colin Collins , Joe W. Gray , Bauke Ylstra
- 申请人地址: US CA Oakland
- 专利权人: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- 当前专利权人: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- 当前专利权人地址: US CA Oakland
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; A61K48/00 ; A61P35/00
摘要:
This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.