发明申请
US20100285519A1 QUINOLINONE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS
有权
喹诺酮 - 羧酰胺化合物作为5-HT4受体激动剂
- 专利标题: QUINOLINONE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS
- 专利标题(中): 喹诺酮 - 羧酰胺化合物作为5-HT4受体激动剂
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申请号: US12782915申请日: 2010-05-19
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公开(公告)号: US20100285519A1公开(公告)日: 2010-11-11
- 发明人: Daniel Marquess , Paul R. Fatheree , S. Derek Turner , Daniel D. Long , Seok-ki Choi , Adam A. Goldblum , Daniel Genov
- 申请人: Daniel Marquess , Paul R. Fatheree , S. Derek Turner , Daniel D. Long , Seok-ki Choi , Adam A. Goldblum , Daniel Genov
- 主分类号: C12Q1/02
- IPC分类号: C12Q1/02
摘要:
The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds of Formula (I). The invention also provides pharmaceutical compositions comprising such compounds, the use such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds. Wherein; R1 is hydrogen, halo, hydroxy, C1-4 alkyl, or C1-4 alkoxy; R2 is C3-4 alkyl, or C3-6cycloalkyl; R3 is hydrogen or C1-3 alkyl: R4 is S(O)2R6 or C(O)R7; R5 is hydrogen, C1-3alkyl, C2-3 alkyl substituted with —OH or C1-3 alkoxy, or —CH2-pyrydyl; R6 is C1-3 alkyl; or R5 and R6 taken together from C3-4 alkylenyl; and R7 is hydrogen, C1-3alkyl, or pyrydyl; or pharmaceutically-acceptable salt or solvate or stereoisomer thereof.
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