发明申请
US20100291023A1 METHOD FOR EXTENDING THE HALF-LIFE OF EXOGENOUS OR ENDOGENOUS SOLUBLE MOLECULES
审中-公开
扩增异源或内源可溶性分子半衰期的方法
- 专利标题： METHOD FOR EXTENDING THE HALF-LIFE OF EXOGENOUS OR ENDOGENOUS SOLUBLE MOLECULES
- 专利标题（中）： 扩增异源或内源可溶性分子半衰期的方法
-
申请号： US12602434申请日： 2008-05-30
-
公开(公告)号： US20100291023A1公开(公告)日： 2010-11-18
- 发明人: Janine Schuurman , Tom Vink , Jan Van de Winkel , Aran Frank Labrijn , Paul Parren , Frank Beurskens , Willem Karel Bleeker , Patrick Van Berkel
- 申请人： Janine Schuurman , Tom Vink , Jan Van de Winkel , Aran Frank Labrijn , Paul Parren , Frank Beurskens , Willem Karel Bleeker , Patrick Van Berkel
- 申请人地址： DK Copenhagen
- 专利权人： GENMAB A/S
- 当前专利权人： GENMAB A/S
- 当前专利权人地址： DK Copenhagen
- 优先权： DKPA200700793 20070531
- 国际申请： PCT/DK2008/050128 WO 20080530
- 主分类号： A61K38/20
- IPC分类号： A61K38/20 ; A61K38/21 ; A61K39/395 ; C07K16/44 ; C07K16/42
摘要：
The present invention relates to methods for extending the in vivo half-life of an exogenous soluble therapeutic molecule administered to a subject, by administering to said subject the exogenous soluble molecule and a monovalent antibody that binds to the exogenous soluble molecule, as well as method for treating a disease or disorder associated with an insufficient level of an endogenous soluble molecule in a subject, by administering to said subject a monovalent antibody that binds to the endogenous soluble molecule.
信息查询
IPC分类:
