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1.发明申请METHOD FOR EXTENDING THE HALF-LIFE OF EXOGENOUS OR ENDOGENOUS SOLUBLE MOLECULES 审中-公开扩增异源或内源可溶性分子半衰期的方法公开(公告)号：US20100291023A1
公开(公告)日：2010-11-18
申请号：US12602434
申请日：2008-05-30
申请人： Janine Schuurman , Tom Vink , Jan Van de Winkel , Aran Frank Labrijn , Paul Parren , Frank Beurskens , Willem Karel Bleeker , Patrick Van Berkel
发明人： Janine Schuurman , Tom Vink , Jan Van de Winkel , Aran Frank Labrijn , Paul Parren , Frank Beurskens , Willem Karel Bleeker , Patrick Van Berkel
IPC分类号： A61K38/20 , A61K38/21 , A61K39/395 , C07K16/44 , C07K16/42
CPC分类号： C07K16/283 , C07K16/2812 , C07K16/2863 , C07K16/2887 , C07K2317/732
摘要： The present invention relates to methods for extending the in vivo half-life of an exogenous soluble therapeutic molecule administered to a subject, by administering to said subject the exogenous soluble molecule and a monovalent antibody that binds to the exogenous soluble molecule, as well as method for treating a disease or disorder associated with an insufficient level of an endogenous soluble molecule in a subject, by administering to said subject a monovalent antibody that binds to the endogenous soluble molecule.
摘要翻译： 本发明涉及通过向所述受试者施用外源可溶性分子和结合外源可溶性分子的单价抗体以及方法，用于延长给予受试者的外源可溶性治疗分子的体内半衰期的方法，以及方法 用于治疗与受试者内源性可溶性分子水平不足相关的疾病或病症，通过向所述受试者施用结合内源性可溶性分子的单价抗体。
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2.发明申请TRANSGENIC ANIMALS PRODUCING MONOVALENT HUMAN ANTIBODIES AND ANTIBODIES OBTAINABLE FROM THESE ANIMALS 有权生产从这些动物获得的单一人类抗体和抗体的转基因动物公开(公告)号：US20100306867A1
公开(公告)日：2010-12-02
申请号：US12602419
申请日：2008-05-30
申请人： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Frank Beurskens , Patrick Van Berkel
发明人： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Frank Beurskens , Patrick Van Berkel
IPC分类号： A01K67/027 , C07H21/04 , G01N33/53 , C07K16/18 , C12N15/63
CPC分类号： C07K16/2887 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/283 , C07K16/2863 , C07K2317/21 , C07K2317/55 , C07K2317/732 , C07K2317/77 , C07K2317/90 , C12N15/8509 , C12N2740/16011
摘要： The invention relates to novel non-human transgenic animals, which upon antigenic stimulation are capable of producing monovalent antibodies binding to a selected antigen, modified heavy chain transgenes, methods for producing the non-human transgenic animals, methods for immunizing the non-human transgenic animals for as well as monovalent antibodies obtainable by such immunization methods.
摘要翻译： 本发明涉及新型非人转基因动物，其在抗原刺激时能够产生结合选定抗原的单价抗体，修饰的重链转基因，用于产生非人转基因动物的方法，用于免疫非人转基因动物的方法 动物以及通过这种免疫方法可获得的单价抗体。
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公开(公告)号：US09322035B2
公开(公告)日：2016-04-26
申请号：US12602419
申请日：2008-05-30
申请人： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Frank Beurskens , Patrick Van Berkel
发明人： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Frank Beurskens , Patrick Van Berkel
CPC分类号： C07K16/2887 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/283 , C07K16/2863 , C07K2317/21 , C07K2317/55 , C07K2317/732 , C07K2317/77 , C07K2317/90 , C12N15/8509 , C12N2740/16011
摘要： The invention relates to novel non-human transgenic animals, which upon antigenic stimulation are capable of producing monovalent antibodies binding to a selected antigen, modified heavy chain transgenes, methods for producing the non-human transgenic animals, methods for immunizing the non-human transgenic animals for as well as monovalent antibodies obtainable by such immunization methods.
摘要翻译： 本发明涉及新型非人转基因动物，其在抗原刺激时能够产生结合选定抗原的单价抗体，修饰的重链转基因，用于产生非人转基因动物的方法，用于免疫非人转基因动物的方法 动物以及通过这种免疫方法可获得的单价抗体。
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公开(公告)号：US20100325744A1
公开(公告)日：2010-12-23
申请号：US12602404
申请日：2008-05-30
申请人： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Patrick Van Berkel , Frank Beurskens
发明人： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Patrick Van Berkel , Frank Beurskens
IPC分类号： A01K67/00 , C07K16/00 , C07K16/18 , C07K16/24 , C07K16/22 , C07K16/40 , C07K16/26 , C07K16/42 , A61K39/395 , A61P35/00 , A61P29/00 , A61P37/00 , C07H21/04 , C12P21/06 , C12N1/21 , C12N5/10 , C12N1/15
CPC分类号： C07K16/00 , C07K16/2812 , C07K16/283 , C07K16/2863 , C07K2317/21 , C07K2317/53 , C07K2317/55 , C07K2317/71 , C07K2317/732 , C07K2317/76 , C07K2317/77
摘要： The present invention provides non-glycosylated monovalent antibodies with a long half-life when administered in vivo, methods of making such monovalent antibodies, pharmaceutical compositions comprising such antibodies, and uses of the monovalent antibodies.
摘要翻译： 本发明提供了在体内施用时具有长半衰期的非糖基化单价抗体，制备这种单价抗体的方法，包含此类抗体的药物组合物和单价抗体的用途。
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5.发明申请RECOMBINANT FUCOSE MODIFIED MONOVALENT HALF-ANTIBODIES OBTAINED BY MOLECULAR ENGINEERING 审中-公开通过分子工程获得的重组型FUCOSE修饰的单价抗体公开(公告)号：US20100255012A1
公开(公告)日：2010-10-07
申请号：US12602407
申请日：2008-05-30
申请人： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Frank Beurskens , Patrick Van Berkel
发明人： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Frank Beurskens , Patrick Van Berkel
CPC分类号： C07K16/1063 , A61K2039/505 , C07K16/00 , C07K16/283 , C07K16/2863 , C07K16/2887 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2317/732 , C07K2317/77
摘要： Glycosylated monovalent antibodies binding to selected antigens with a low or lacking fucose content, which are capable of inducing antibody dependent cellular cytotoxicity (ADCC) on cells expressing the selected antigens in the presence of effector cells, methods for producing the monovalent antibodies, pharmaceutical compositions comprising such monovalent antibodies and use thereof for different diagnostic and therapeutic applications.
摘要翻译： 能够在效应细胞存在下表达所选抗原的细胞上诱导抗体依赖性细胞毒性（ADCC）的低或不含岩藻糖含量的选定抗原结合的糖基化单价抗体，用于产生单价抗体的方法，包含 这种单价抗体及其用于不同诊断和治疗应用。
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公开(公告)号：US20110045007A1
公开(公告)日：2011-02-24
申请号：US12602416
申请日：2008-05-30
申请人： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrljn , Paul Parren , Willem Karel Bleeker , FRank Beurskens , Patrick Van Berkel
发明人： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrljn , Paul Parren , Willem Karel Bleeker , FRank Beurskens , Patrick Van Berkel
IPC分类号： A61K39/395 , C12P21/02 , C12N9/96 , C12N5/071 , C12N5/10 , C12N1/21 , C12N1/15 , C12N15/63 , C07K16/00 , C07K19/00 , C07K16/46 , A61P29/00 , A61P35/00 , A61P3/10 , A61P25/16 , A61P25/08 , A61P25/18 , A61P25/00 , A61P31/04 , A61P31/12 , A61P31/10 , A61P7/00 , A61P11/06 , A61P25/24 , A61P7/02 , A61P33/00
CPC分类号： C07K16/28 , A61K47/6813 , A61K47/6849 , C07K16/283 , C07K16/2863 , C07K16/2887 , C07K2317/53 , C07K2317/732 , C07K2317/77 , C07K2319/33
摘要： The present invention provides fusion proteins comprising a first molecule, and a second molecule which is a monovalent immunoglobulin or a fragment of a monovalent immunoglobulin with a long half-life when administered in vivo, methods of making such fusion proteins, pharmaceutical compositions comprising such fusion proteins, and uses thereof.
摘要翻译： 本发明提供包含第一分子和第二分子的融合蛋白，其是当体内施用时具有长半衰期的单价免疫球蛋白或单价免疫球蛋白的片段的第二分子，制备此类融合蛋白的方法，包含这种融合的药物组合物 蛋白质及其用途。
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公开(公告)号：US10155816B2
公开(公告)日：2018-12-18
申请号：US12095023
申请日：2006-11-28
申请人： Paul Parren , Janine Schuurman , Tom Vink , Willem Karel Bleeker , Jan Van De Winkel , Patrick Van Berkel , Frank Beurskens
发明人： Paul Parren , Janine Schuurman , Tom Vink , Willem Karel Bleeker , Jan Van De Winkel , Patrick Van Berkel , Frank Beurskens
摘要： The present invention provides monovalent antibodies with a long half-life when administered in vivo, methods of making such monovalent antibodies, pharmaceutical compositions comprising such antibodies, and uses of the monovalent antibodies.
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公开(公告)号：US20090226421A1
公开(公告)日：2009-09-10
申请号：US12095023
申请日：2006-11-28
申请人： Paul Parren , Janine Schuurman , Tom Vink , Willem Karel Bleeker , Jan Van De Winkel , Patrick Van Berkel , Frank Beurskens
发明人： Paul Parren , Janine Schuurman , Tom Vink , Willem Karel Bleeker , Jan Van De Winkel , Patrick Van Berkel , Frank Beurskens
CPC分类号： C07K16/2863 , C07K16/2812 , C07K16/283 , C07K16/2887 , C07K2317/21 , C07K2317/53 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77
摘要： The present invention provides monovalent antibodies with a long half-life when administered in vivo, methods of making such monovalent antibodies, pharmaceutical compositions comprising such antibodies, and uses of the monovalent antibodies.
摘要翻译： 本发明提供了在体内施用时具有长半衰期的单价抗体，制备这种单价抗体的方法，包含这种抗体的药物组合物和单价抗体的用途。
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公开(公告)号：US09150658B2
公开(公告)日：2015-10-06
申请号：US13133811
申请日：2009-12-09
申请人： Sandra Verploegen , David P. E. Satijn , Rene Hoet , Paul Parren , Jan Van De Winkel , Vibeke Miller Breinholt , Eva Ehrnrooth , Ole Baadsgaard , Tom Vink , Willem Karel Bleeker , Mischa Houtkamp , Maroeska Oudshoorn , Rob N. De Jong
发明人： Sandra Verploegen , David P. E. Satijn , Rene Hoet , Paul Parren , Jan Van De Winkel , Vibeke Miller Breinholt , Eva Ehrnrooth , Ole Baadsgaard , Tom Vink , Willem Karel Bleeker , Mischa Houtkamp , Maroeska Oudshoorn , Rob N. De Jong
IPC分类号： C07K16/36 , A61K39/395
CPC分类号： C07K16/36 , A61K39/395 , A61K2039/505 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： Isolated human monoclonal antibodies which bind to human TF and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.
摘要翻译： 公开了结合人TF和相关的基于抗体的组合物和分子的分离的人单克隆抗体。 还公开了包含抗体的药物组合物，以及使用抗体的治疗和诊断方法。
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公开(公告)号：US20110300156A1
公开(公告)日：2011-12-08
申请号：US13133811
申请日：2009-12-09
申请人： Sandra Verploegen , David P.E. Satijn , Rene Hoet , Paul Parren , Jan Van De Winkel , Vibeke Miller Breinholt , Eva Ehrnrooth , Ole Baadsgaard , Tom Vink , Willem Karel Bleeker , Mischa Houtkamp , Maroeska Oudshoorn , Rob N. De Jong
发明人： Sandra Verploegen , David P.E. Satijn , Rene Hoet , Paul Parren , Jan Van De Winkel , Vibeke Miller Breinholt , Eva Ehrnrooth , Ole Baadsgaard , Tom Vink , Willem Karel Bleeker , Mischa Houtkamp , Maroeska Oudshoorn , Rob N. De Jong
IPC分类号： A61K39/395 , C12P21/00 , C12N15/63 , A61P35/00 , C12N1/15 , C12N1/19 , C12N1/21 , G01N33/573 , C07K16/40 , C12N5/10
CPC分类号： C07K16/36 , A61K39/395 , A61K2039/505 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： Isolated human monoclonal antibodies which bind to human TF and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.
摘要翻译： 公开了结合人TF和相关的基于抗体的组合物和分子的分离的人单克隆抗体。 还公开了包含抗体的药物组合物，以及使用抗体的治疗和诊断方法。
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