发明申请
US20100292171A1 Competitive Regulation of Hepcidin mRNA by Soluble and Cell-Associated Hemojuvelin
审中-公开
通过可溶性和细胞相关血红素的竞争性调节Hepcidin mRNA
- 专利标题： Competitive Regulation of Hepcidin mRNA by Soluble and Cell-Associated Hemojuvelin
- 专利标题（中）： 通过可溶性和细胞相关血红素的竞争性调节Hepcidin mRNA
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申请号： US12775032申请日： 2010-05-06
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公开(公告)号： US20100292171A1公开(公告)日： 2010-11-18
- 发明人: TOMAS GANZ , LAN LIN , YIGAL P. GOLDBERG
- 申请人： TOMAS GANZ , LAN LIN , YIGAL P. GOLDBERG
- 主分类号： A61K38/17
- IPC分类号： A61K38/17 ; C07K14/435 ; G01N33/68 ; C12N15/63 ; C12N5/07 ; A61P3/00 ; A61P3/02
摘要：
Disclosed herein are hemojuvelin-specific siRNAs that vary hemojuvelin mRNA concentration. Also disclosed herein, GPI-hemojuvelin positively regulated hepcidin mRNA expression, independently of the IL-6 pathway, whereas soluble hemojuvelin (s-hemojuvelin) suppressed hepcidin mRNA expression in primary human hepatocytes in a log-linear dosedependent manner. Disclosed are compositions and methods for modulating diseases of iron metabolism and hepcidin expression or hepcidin levels.
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