专利检索 ap:("TOMAS GANZ" OR "LAN LIN" OR "YIGAL P. GOLDBERG") AND inv:"YIGAL P. GOLDBERG" 第 1 页

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发明申请
Competitive Regulation of Hepcidin mRNA by Soluble and Cell-Associated Hemojuvelin 审中-公开
标题翻译：通过可溶性和细胞相关血红素的竞争性调节Hepcidin mRNA

公开(公告)号：US20100292171A1

公开(公告)日：2010-11-18

申请号：US12775032

申请日：2010-05-06

申请人： TOMAS GANZ , LAN LIN , YIGAL P. GOLDBERG

发明人： TOMAS GANZ , LAN LIN , YIGAL P. GOLDBERG

IPC分类号： A61K38/17 , C07K14/435 , G01N33/68 , C12N15/63 , C12N5/07 , A61P3/00 , A61P3/02

CPC分类号： A61K38/1709

摘要： Disclosed herein are hemojuvelin-specific siRNAs that vary hemojuvelin mRNA concentration. Also disclosed herein, GPI-hemojuvelin positively regulated hepcidin mRNA expression, independently of the IL-6 pathway, whereas soluble hemojuvelin (s-hemojuvelin) suppressed hepcidin mRNA expression in primary human hepatocytes in a log-linear dosedependent manner. Disclosed are compositions and methods for modulating diseases of iron metabolism and hepcidin expression or hepcidin levels.

摘要翻译： 本文公开了改变hemojuvelin mRNA浓度的hemojuvelin特异性siRNA。本文还公开了GPI-hemojuvelin与IL-6途径无关地正调节hepcidin mRNA表达，而可溶性hemojuvelin（s-hemojuvelin）以对数线性依赖方式抑制原代人肝细胞中的铁调素mRNA表达。公开了用于调节铁代谢和铁调素表达或铁调素水平的疾病的组合物和方法。