发明申请
US20100292184A1 17BETA-CYANO-19-ANDROST-4-ENE DERIVATIVE, ITS USE AND MEDICAMENTS COMPRISING THE DERIVATIVE
审中-公开
17BETA-CYANO-19-ANDROST-4-ENE DERIVATIVE,其使用和药物包含衍生物
- 专利标题: 17BETA-CYANO-19-ANDROST-4-ENE DERIVATIVE, ITS USE AND MEDICAMENTS COMPRISING THE DERIVATIVE
- 专利标题(中): 17BETA-CYANO-19-ANDROST-4-ENE DERIVATIVE,其使用和药物包含衍生物
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申请号: US12664099申请日: 2008-06-12
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公开(公告)号: US20100292184A1公开(公告)日: 2010-11-18
- 发明人: Joachim Kuhnke , Jan Huebner , Rolf Bohlmann , Thomas Frenzel , Ulrich Klar , Frederik Menges , Sven Ring , Steffen Borden , Hans Peter Muhn , Katja Prelle
- 申请人: Joachim Kuhnke , Jan Huebner , Rolf Bohlmann , Thomas Frenzel , Ulrich Klar , Frederik Menges , Sven Ring , Steffen Borden , Hans Peter Muhn , Katja Prelle
- 申请人地址: DE Berlin
- 专利权人: BAYER SCHERING PHARMA AG
- 当前专利权人: BAYER SCHERING PHARMA AG
- 当前专利权人地址: DE Berlin
- 优先权: DE102007027635.6 20070612
- 国际申请: PCT/EP2008/057427 WO 20080612
- 主分类号: A61K31/56
- IPC分类号: A61K31/56 ; C07J53/00 ; C07J41/00 ; A61K31/695 ; A61K31/565 ; A61P15/18 ; A61P5/24 ; A61P5/34 ; A61P5/42
摘要:
The 17β-cyano-19-androst-4-ene derivatives of the present invention possess gestagenic activity. They have the general chemical formula 1, in which Z is selected from the group comprising O, two hydrogen atoms, NOR and NNHSO2R, in which R is hydrogen or C1-C4-alkyl, R1, R2 are each independently hydrogen or methyl, or R1 and R2 together form methylene or are omitted with formation of a double bond between C1 and C2, R4 is hydrogen or halogen, furthermore either: R6a, R6b together form methylene or 1,2-ethanediyl or R6a is hydrogen and R6b is selected from the group comprising hydrogen, methyl and hydroxymethylene, and R7 is selected from the group comprising hydrogen, C1-C4-alkyl, C2-C3-alkenyl and cyclopropyl, or: R6a hydrogen and R6b and R7 together form methylene or are omitted with formation of a double bond between C6 and C7 or: R6a is methyl and R6b and R7 are omitted with formation of a double bond between C6 and C7, R15, R16 are hydrogen or together form methylene, R17 is selected from the group comprising hydrogen, C1-C4-alkyl and allyl, and moreover comprise their solvates, hydrates, stereoisomers, diastereomers, enantiomers and salts, with the proviso that particular compounds are excluded.
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