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1.发明授权Herbicidally and fungicidally active 3-phenylisoxazoline-5-carboxamides and 3-phenylisoxazoline-5-thioamides 有权除草和杀真菌活性3-苯基异恶唑啉-5-甲酰胺和3-苯基异恶唑啉-5-硫代酰胺公开(公告)号：US09078442B2
公开(公告)日：2015-07-14
申请号：US14006280
申请日：2012-03-26
申请人： Lothar Willms , Monika H Schmitt , Thomas Frenzel , Klaus Bernhard Haaf , Isolde Häuser-Hahn , Ines Heinemann , Elmar Gatzweiler , Christopher Hugh Rosinger , Heinz Kehne , Jan Dittgen , Dieter Feucht , Martin Jeffrey Hills , Philippe Rinolfi
发明人： Lothar Willms , Monika H Schmitt , Thomas Frenzel , Klaus Bernhard Haaf , Isolde Häuser-Hahn , Ines Heinemann , Elmar Gatzweiler , Christopher Hugh Rosinger , Heinz Kehne , Jan Dittgen , Dieter Feucht , Martin Jeffrey Hills , Philippe Rinolfi
IPC分类号： A01N25/32 , A01N43/40 , A01N43/36 , A01N43/54 , A01N43/82 , A01N43/78 , A01N43/80 , A61K31/505 , A61K31/44 , A61K31/41 , A61K31/425 , A61K31/42 , C07D239/24 , C07D401/02 , C07D261/02 , C07D413/02 , C07D285/08 , C07D271/06 , C07D413/04 , A01N43/56 , C07D261/04 , C07D413/12 , C07D417/12
CPC分类号： A01N43/80 , A01N25/32 , A01N43/40 , A01N43/54 , A01N43/56 , A01N43/82 , A61K31/505 , C07D261/02 , C07D261/04 , C07D271/06 , C07D413/04 , C07D413/12 , C07D417/12
摘要： 3-Phenylisoxazoline-5-carboxamides and 3-phenylisoxazoline-5-thioamides of the formula (I) and their use as herbicides and fungicides are described. In this formula (I), X, X2 to X6, R1 to R4 are radicals such as hydrogen, halogen and organic radicals such as substituted alkyl. A is a bond or a divalent unit. Y is a chalcogen.
摘要翻译： 描述了式（I）的3-苯基异恶唑啉-5-甲酰胺和3-苯基异恶唑啉-5-硫代酰胺及其作为除草剂和杀真菌剂的用途。 在该式（I）中，X，X 2至X 6，R 1至R 4为氢，卤素和有机基团如取代烷基等基团。 A是键或二价单元。 Y是硫属元素。
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2.发明申请15,16-Methylene-17-hydroxy-19-nor-21-carboxylic acid-steroid Y-lactone derivative, use thereof and medicinal products containing the derivative 审中-公开15,16-亚甲基-17-羟基-19-去甲-21-羧酸类固醇Y-内酯衍生物及其衍生物的用途公开(公告)号：US20110015162A1
公开(公告)日：2011-01-20
申请号：US12811002
申请日：2008-12-23
申请人： Ulrich Klar , Joachim Kuhnke , Rolf Bohlmann , Jan Huebner , Sven Ring , Thomas Frenzel , Frederik Menges , Steffen Borden , Hans Peter Muhn , Katja Prelle
发明人： Ulrich Klar , Joachim Kuhnke , Rolf Bohlmann , Jan Huebner , Sven Ring , Thomas Frenzel , Frederik Menges , Steffen Borden , Hans Peter Muhn , Katja Prelle
CPC分类号： C07J53/008
摘要： The invention relates to 15,16-methylene-17-hydroxy-19-nor-21-carboxylic acid-steroid γ-lactone derivatives with the general chemical formula I, and R4, R6a, R6b, R7 and Z have the meanings stated in claim 1, and their solvates, hydrates, stereoisomers and salts. The invention further relates to the use of these derivatives for the production of a medicinal product for oral contraception and for the treatment of pre-, peri- and postmenopausal complaints and medicinal products that contain said derivatives. The derivatives according to the invention have a progestational and in preferred cases additionally an antimineralocorticoid and neutral to slightly androgenic action.
摘要翻译： 本发明涉及具有一般化学式I的15,16-亚甲基-17-羟基-19-去甲-21-羧酸 - 类固醇γ-内酯衍生物，且R4，R6a，R6b，R7和Z具有以下含义： 权利要求1及其溶剂合物，水合物，立体异构体和盐。 本发明还涉及这些衍生物用于生产口服避孕用药物和用于治疗前，绝经前和绝经后的投诉和含有所述衍生物的药用产品的用途。 根据本发明的衍生物具有促孕作用，在优选情况下另外具有抗皮质激素和中性至轻度雄激素作用。
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公开(公告)号：US20090075987A1
公开(公告)日：2009-03-19
申请号：US12178325
申请日：2008-07-23
申请人： Lars Wortmann , Marcus Koppitz , Hans Peter Muhn , Thomas Frenzel , Florian Peter Liesener , Anna Schrey , Ronald Kuehne
发明人： Lars Wortmann , Marcus Koppitz , Hans Peter Muhn , Thomas Frenzel , Florian Peter Liesener , Anna Schrey , Ronald Kuehne
IPC分类号： A61K31/541 , C07D209/18 , A61K31/404 , A61P15/08 , A61P19/10 , C07D417/02
CPC分类号： C07D209/14 , C07D405/12
摘要： The present invention relates to acyltryptophanols of the general formula I, in which R1, R2, R3, Q and X have the meaning as defined in the description.The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.
摘要翻译： 本发明涉及通式Ⅰ的酰基色氨酸，其中R1，R2，R3，Q和X具有说明书中定义的含义。 根据本发明的化合物是有效的FSH拮抗剂，可用于例如男性或女性的生育控制，或用于预防和/或治疗骨质疏松症。
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4.发明授权Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis 失效含有全氟烷基的金属络合物，其制备方法及其在核磁共振诊断中的应用公开(公告)号：US07226578B2
公开(公告)日：2007-06-05
申请号：US10957628
申请日：2004-10-05
申请人： Johannes Platzek , Ulrich Niedballa , Bernd Radüchel , Wolfgang Schlecker , Hanns-Joachim Weinmann , Thomas Frenzel , Bernd Misselwitz , Wolfgang Ebert
发明人： Johannes Platzek , Ulrich Niedballa , Bernd Radüchel , Wolfgang Schlecker , Hanns-Joachim Weinmann , Thomas Frenzel , Bernd Misselwitz , Wolfgang Ebert
IPC分类号： A61B5/055
CPC分类号： C07D295/26 , A61K49/0002 , A61K49/0004 , B65D25/16 , B65D47/0847 , B65D83/0055 , C07C229/76 , C07C237/10 , C07D257/02
摘要： The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy.The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.
摘要翻译： 本发明涉及新的单体，全氟烷基取代的金属络合物，其生产方法及其在诊断和治疗中的应用。 根据本发明的化合物特别适用于核自旋断层扫描（MRT）中的体内造影剂。 它们可优选用作血液池剂和淋巴药剂。
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5.发明授权Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes 失效级联聚合物复合物，其制备方法和含有所述复合物的药剂公开(公告)号：US07211241B2
公开(公告)日：2007-05-01
申请号：US10686717
申请日：2003-10-17
IPC分类号： A61B5/055 , A61K49/04 , C07F5/00 , C07D225/00 , C08F283/00
CPC分类号： C07D487/08 , A61K49/04 , A61K49/085 , A61K49/124 , A61K51/065 , C07C229/76 , C07C237/42 , C07D251/54 , C07D257/02 , C07K14/001 , Y10S424/16
摘要： Described are new cascade polymer complexes, compositions containing them and use of the complexes in diagnosis and therapy, particularly for magnetic resonance imaging and computer tomography imaging.
摘要翻译： 描述了新的级联聚合物复合物，含有它们的组合物和复合物在诊断和治疗中的用途，特别是用于磁共振成像和计算机断层摄影成像。
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公开(公告)号：US20060093554A1
公开(公告)日：2006-05-04
申请号：US11223203
申请日：2005-09-12
申请人： Johannes Platzek , Ulrich Niedballa , Bernd Raduechel , Peter Mareski , Bernd Misselwitz , Thomas Frenzel , Hanns-Joachim Weinmann
发明人： Johannes Platzek , Ulrich Niedballa , Bernd Raduechel , Peter Mareski , Bernd Misselwitz , Thomas Frenzel , Hanns-Joachim Weinmann
IPC分类号： A61K51/00
CPC分类号： A61K49/10 , A61K49/06 , A61K49/085
摘要： This invention describes new galenical formulations that contain paramagnetic and diamagnetic perfluoroalkyl-containing compounds. The new formulations are suitable as contrast media for nuclear spin tomography.
摘要翻译： 本发明描述了含有顺磁性和反抗磁性全氟烷基的化合物的新的盖仑制剂。 新制剂适用于核自旋层析成像的造影剂。
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7.发明授权Metal complexes that contain perfluoroalkly, process for their production and their use in NMR diagnosis 失效含有全氟烷烃的金属络合物，其生产过程及其在核磁共振诊断中的应用公开(公告)号：US06468502B1
公开(公告)日：2002-10-22
申请号：US09435918
申请日：1999-11-08
申请人： Johannes Platzek , Ulrich Niedballa , Bernd Radüchel , Wolfgang Schlecker , Hanns-Joachim Weinmann , Thomas Frenzel , Bernd Misselwitz , Wolfgang Ebert
发明人： Johannes Platzek , Ulrich Niedballa , Bernd Radüchel , Wolfgang Schlecker , Hanns-Joachim Weinmann , Thomas Frenzel , Bernd Misselwitz , Wolfgang Ebert
IPC分类号： A61K5100
CPC分类号： C07D295/26 , A61K49/0002 , A61K49/0004 , B65D25/16 , B65D47/0847 , B65D83/0055 , C07C229/76 , C07C237/10 , C07D257/02
摘要： The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.
摘要翻译： 本发明涉及新的单体，全氟烷基取代的金属络合物，其制备方法及其在诊断和治疗中的用途。根据本发明的化合物特别适用于核自旋断层扫描（MRT）中的体内造影剂。 它们可优选用作血液池剂和淋巴药剂。
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8.发明授权3-, 8-substituted deuteroporphyrin derivatives, pharmaceutical agents that contain the latter, process for their production and their use in photodynamic therapy and MRI diagnosis 失效3-取代的氘代卟啉衍生物，含有后者的药剂，其制备方法及其在光动力疗法和MRI诊断中的应用
公开(公告)号：US6136841A
公开(公告)日：2000-10-24
申请号：US323996
申请日：1999-06-02
申请人： Johannes Platzek , Ulrich Niedballa , Bernd Raduechel , Wolfgang Ebert , Hanns-Joachim Weinmann , Thomas Frenzel
发明人： Johannes Platzek , Ulrich Niedballa , Bernd Raduechel , Wolfgang Ebert , Hanns-Joachim Weinmann , Thomas Frenzel
IPC分类号： A61K41/00 , A61K49/08 , C07D487/22 , A61K49/00
CPC分类号： C07D487/22 , A61K41/0071 , A61K49/085 , A61K49/10
摘要： 3-,8-substituted deuteroporphyrin derivatives with various substituents in the 13- and 17-positions of the porphyrin skeleton are suitable as pharmaceutical agents for use in photodynamic therapy (PDT) and for MRI therapy monitoring.
摘要翻译： 在卟啉骨架的13位和17位上具有各种取代基的3-取代的氘代卟啉衍生物适用于光动力疗法（PDT）和MRI治疗监测中的药剂。
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9.发明授权Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use and process for their production 失效衍生的DTPA复合物，含有这些化合物的药剂，它们的用途和制备方法
公开(公告)号：US5733522A
公开(公告)日：1998-03-31
申请号：US495473
申请日：1995-09-29
申请人： Heribert Schmitt-Willich , Johannes Platzek , Heinz Gries , Bernd Raduchel , Orlin Petrov , Andreas Muhler , Thomas Frenzel , Hubert Vogler , Hans Bauer , Klaus Nickisch , Jean-Claude Hilscher
发明人： Heribert Schmitt-Willich , Johannes Platzek , Heinz Gries , Bernd Raduchel , Orlin Petrov , Andreas Muhler , Thomas Frenzel , Hubert Vogler , Hans Bauer , Klaus Nickisch , Jean-Claude Hilscher
IPC分类号： A61K49/00 , A61K49/04 , A61K49/06 , C07C229/16 , C07C229/76 , A61B5/055
CPC分类号： A61K49/06 , C07C229/16 , C07C229/76 , Y10S514/836 , Y10T436/24
摘要： The invention relates to complex compound as well as their salts consisting of at least one metal ion and one complexing agent of general formula I ##STR1## in which Z.sup.1, Z.sup.2 and s have different meanings, as well as their use for the production of agents for radiation therapy and for NMR diagnosis and diagnostic radiology, especially for contrasting the hepatobiliary system. Further, the invention relates to a process for the production of these compounds and agents.
摘要翻译： PCT No.PCT / EP94 / 00033 Sec。 371 1995年9月29日第 102（e）1995年9月29日PCT PCT 1994年1月8日PCT公布。 第WO94 / 17029号公报 日期：1994年8月4日本发明涉及复合化合物及其由至少一种金属离子和一种通式I（式I）的络合剂组成的盐，其中Z1，Z2和s具有不同的含义，如 以及它们用于生产放射治疗药物和核磁共振诊断和诊断放射学的用途，特别是用于对比肝胆系统。 此外，本发明涉及一种生产这些化合物和试剂的方法。
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10.发明授权17-(1′propenyl)-17-3′-oxidoestra-4-en-3-one derivative, use thereof, and medicament containing said derivative 有权17-（1'丙烯基）-17-3'-氧代雌-4-烯-3-酮衍生物，其用途和含有所述衍生物的药物公开(公告)号：US09034856B2
公开(公告)日：2015-05-19
申请号：US12810858
申请日：2008-12-23
申请人： Ulrich Klar , Joachim Kuhnke , Rolf Bohlmann , Jan Hübner , Sven Ring , Thomas Frenzel , Frederik Menges , Steffen Borden , Hans Peter Muhn , Katja Prelle
发明人： Ulrich Klar , Joachim Kuhnke , Rolf Bohlmann , Jan Hübner , Sven Ring , Thomas Frenzel , Frederik Menges , Steffen Borden , Hans Peter Muhn , Katja Prelle
CPC分类号： C07J21/00 , C07J41/0016 , C07J53/001 , C07J53/007
摘要： The invention relates to 17-(1′-propenyl)-17-3′-oxidoestra-4-en-3-one derivatives with the general chemical formula I, where the residues Z, R4, R6a, R6b, R7, R15, R16a, R16b and R18 have the meanings stated in Claim 1, and their solvates, hydrates and salts, including all stereoisomers of these compounds. The invention further relates to the use of these derivatives for the production of a medicinal product for oral contraception and for the treatment of pre-, peri- and postmenopausal complaints and medicinal products that contain said derivatives, and in particular application in the aforementioned indications. The derivatives according to the invention have a progestational and in preferred cases additionally an antimineralocorticoid and neutral to slightly androgenic action.
摘要翻译： 本发明涉及具有一般化学式I的17-（1'-丙烯基）-17-3'-氧代雌-4-烯-3-酮衍生物，其中残基Z，R4，R6a，R6b，R7，R15， R16a，R16b和R18具有权利要求1所述的含义，及其溶剂合物，水合物和盐，包括这些化合物的所有立体异构体。 本发明还涉及这些衍生物用于生产口服避孕用药物和用于治疗绝经前，绝经期和绝经后的投诉和含有所述衍生物的药用产品的用途，特别是在上述适应症中的应用。 根据本发明的衍生物具有促孕作用，在优选情况下另外具有抗皮质激素和中性至轻度雄激素作用。
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