发明申请
US20100298331A1 TRIAZINONE AND DIAZINONE DERIVATIVES USEFUL AS HSP90 INHIBITORS
有权
TRIAZINONE和DIAZINONE衍生物作为HSP90抑制剂有用
- 专利标题： TRIAZINONE AND DIAZINONE DERIVATIVES USEFUL AS HSP90 INHIBITORS
- 专利标题（中）： TRIAZINONE和DIAZINONE衍生物作为HSP90抑制剂有用
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申请号： US12593147申请日： 2008-03-24
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公开(公告)号： US20100298331A1公开(公告)日： 2010-11-25
- 发明人: Chi-Wan Lee , Teresa Przewloka , Weiwen Ying , Minghu Song , Zhenjian Du , Kevin Foley , Dan Zhou , Shuzhen Qin
- 申请人： Chi-Wan Lee , Teresa Przewloka , Weiwen Ying , Minghu Song , Zhenjian Du , Kevin Foley , Dan Zhou , Shuzhen Qin
- 专利权人： Synta Pharmaceuticals Corp.
- 当前专利权人： Synta Pharmaceuticals Corp.
- 国际申请： PCT/US2008/003810 WO 20080324
- 主分类号： A61K31/53
- IPC分类号： A61K31/53 ; C12N5/071 ; C07D239/10 ; C07D487/04 ; C07D491/04 ; C07D253/065 ; A61K31/505 ; A61K31/519 ; A61P35/00
摘要：
The present invention relates to compounds according to formulae (IA) to (ID) and compositions that inhibit the activity of Hsp90. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a compound of the invention, or a composition comprising such a compound.