发明申请
US20100303923A1 Endotoxin adsorbent for the prevention and treatment of autoimmune diseases
有权
内毒素吸附剂用于预防和治疗自身免疫性疾病
- 专利标题： Endotoxin adsorbent for the prevention and treatment of autoimmune diseases
- 专利标题（中）： 内毒素吸附剂用于预防和治疗自身免疫性疾病
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申请号： US12804945申请日： 2010-08-02
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公开(公告)号： US20100303923A1公开(公告)日： 2010-12-02
- 发明人: Kuniaki Terato , Hiroshi Shionoya , Sadaichi Iwashita
- 申请人： Kuniaki Terato , Hiroshi Shionoya , Sadaichi Iwashita
- 专利权人： Hiroshi SHIONOYA,CHONDREX INC.,MUROMACHI CHEMICAL CO., LTD.
- 当前专利权人： Hiroshi SHIONOYA,CHONDREX INC.,MUROMACHI CHEMICAL CO., LTD.
- 主分类号： A61K38/12
- IPC分类号： A61K38/12 ; A61K9/14 ; A61P29/00
摘要：
It is believed that the abnormal absorption of endotoxin present in the gastrointestinal tract relates to the pathogenesis of autoimmune diseases such as rheumatoid arthritis. In an animal model for rheumatoid arthritis, it is observed that arthritis is improved by removing endotoxin. The present invention provides an endotoxin-adsorbent, which is capable of removing endotoxin in the gastrointestinal tract and can be administered to humans safely. By using a non-digestible and non-absorbable, and therefore, safe endotoxin-adsorbent, which has a high endotoxin-binding capacity for removing large amounts of endotoxin present in the gastrointestinal tract, it is possible to prevent and treat autoimmune diseases such as rheumatoid arthritis.
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