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1.发明授权公开(公告)号：US08287911B2
公开(公告)日：2012-10-16
申请号：US12804945
申请日：2010-08-02
CPC分类号： A61K39/39 , A61K2039/541 , A61K2039/55572
摘要： It is believed that the abnormal absorption of endotoxin present in the gastrointestinal tract relates to the pathogenesis of autoimmune diseases such as rheumatoid arthritis. In an animal model for rheumatoid arthritis, it is observed that arthritis is improved by removing endotoxin. The present invention provides an endotoxin-adsorbent, which is capable of removing endotoxin in the gastrointestinal tract and can be administered to humans safely. By using a non-digestible and non-absorbable, and therefore, safe endotoxin-adsorbent, which has a high endotoxin-binding capacity for removing large amounts of endotoxin present in the gastrointestinal tract, it is possible to prevent and treat autoimmune diseases such as rheumatoid arthritis.
摘要翻译： 据信存在于胃肠道中的内毒素的异常吸收涉及自身免疫性疾病如类风湿性关节炎的发病机理。 在类风湿性关节炎的动物模型中，观察到通过去除内毒素来改善关节炎。 本发明提供一种内毒素吸附剂，其能够除去胃肠道内的内毒素并且可以安全地施用于人。 通过使用具有高内毒素结合能力的不可消化和不可吸收的，因而具有高的内毒素结合能力来去除存在于胃肠道中的大量内毒素的安全的内毒素吸附剂，可以预防和治疗自身免疫性疾病，例如 类风湿关节炎。
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2.发明授权Endotoxin-adsorbent for the prevention and treatment of autoimmune diseases 有权内毒素 - 吸附剂用于预防和治疗自身免疫性疾病公开(公告)号：US07799347B2
公开(公告)日：2010-09-21
申请号：US11518393
申请日：2006-09-07
CPC分类号： A61K39/39 , A61K2039/541 , A61K2039/55572
摘要： It is believed that the abnormal absorption of endotoxin present in the gastrointestinal tract relates to the pathogenesis of autoimmune diseases such as rheumatoid arthritis. In an animal model for rheumatoid arthritis, it is observed that arthritis is improved by removing endotoxin. The present invention provides an endotoxin-adsorbent, which is capable of removing endotoxin in the gastrointestinal tract and can be administered to humans safely. By using a non-digestible and non-absorbable, and therefore, safe endotoxin-adsorbent, which has a high endotoxin-binding capacity for removing large amounts of endotoxin present in the gastrointestinal tract, it is possible to prevent and treat autoimmune diseases such as rheumatoid arthritis.
摘要翻译： 据信存在于胃肠道中的内毒素的异常吸收涉及自身免疫性疾病如类风湿性关节炎的发病机理。 在类风湿性关节炎的动物模型中，观察到通过去除内毒素来改善关节炎。 本发明提供一种内毒素吸附剂，其能够除去胃肠道内的内毒素并且可以安全地施用于人。 通过使用具有高内毒素结合能力的不可消化和不可吸收的，并且因此安全的内毒素吸附剂，用于去除存在于胃肠道中的大量内毒素，可以预防和治疗自身免疫疾病，例如 类风湿关节炎。
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3.发明申请公开(公告)号：US20100303923A1
公开(公告)日：2010-12-02
申请号：US12804945
申请日：2010-08-02
CPC分类号： A61K39/39 , A61K2039/541 , A61K2039/55572
摘要： It is believed that the abnormal absorption of endotoxin present in the gastrointestinal tract relates to the pathogenesis of autoimmune diseases such as rheumatoid arthritis. In an animal model for rheumatoid arthritis, it is observed that arthritis is improved by removing endotoxin. The present invention provides an endotoxin-adsorbent, which is capable of removing endotoxin in the gastrointestinal tract and can be administered to humans safely. By using a non-digestible and non-absorbable, and therefore, safe endotoxin-adsorbent, which has a high endotoxin-binding capacity for removing large amounts of endotoxin present in the gastrointestinal tract, it is possible to prevent and treat autoimmune diseases such as rheumatoid arthritis.
摘要翻译： 据信存在于胃肠道中的内毒素的异常吸收涉及自身免疫性疾病如类风湿性关节炎的发病机理。 在类风湿性关节炎的动物模型中，观察到通过去除内毒素来改善关节炎。 本发明提供一种内毒素吸附剂，其能够除去胃肠道内的内毒素并且可以安全地施用于人。 通过使用具有高内毒素结合能力的不可消化和不可吸收的，并且因此安全的内毒素吸附剂，用于去除存在于胃肠道中的大量内毒素，可以预防和治疗自身免疫疾病，例如 类风湿关节炎。
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4.发明申请Endotoxin-adsorbent for the prevention and treatment of autoimmune diseases 有权内毒素 - 吸附剂用于预防和治疗自身免疫性疾病公开(公告)号：US20080063645A1
公开(公告)日：2008-03-13
申请号：US11518393
申请日：2006-09-07
IPC分类号： A61K39/395
CPC分类号： A61K39/39 , A61K2039/541 , A61K2039/55572
摘要： It is believed that the abnormal absorption of endotoxin present in the gastrointestinal tract relates to the pathogenesis of autoimmune diseases such as rheumatoid arthritis. In an animal model for rheumatoid arthritis, it is observed that arthritis is improved by removing endotoxin. The present invention provides endotoxin-adsorbent, which is capable of removing endotoin in gastrointestinal tract and can be administered to humans safely. By using a non-digestible and non-absorbable, and therefore, safe endotoxin-adsorbent, which has a high endotoxin-binding capacity for removing large amounts of endotoxin present in the gastrointestinal tract, it is possible to prevent and treat autoimmune diseases such as rheumatoid arthritis.
摘要翻译： 据信存在于胃肠道中的内毒素的异常吸收涉及自身免疫性疾病如类风湿性关节炎的发病机理。 在类风湿性关节炎的动物模型中，观察到通过去除内毒素来改善关节炎。 本发明提供能够去除胃肠道内毒素并能够安全地施用于人的内毒素吸附剂。 通过使用具有高内毒素结合能力的不可消化和不可吸收的，并且因此安全的内毒素吸附剂，用于去除存在于胃肠道中的大量内毒素，可以预防和治疗自身免疫疾病，例如 类风湿关节炎。
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公开(公告)号：US06755981B2
公开(公告)日：2004-06-29
申请号：US10313816
申请日：2002-12-05
申请人： Kuniaki Terato
发明人： Kuniaki Terato
IPC分类号： A01K6304
CPC分类号： A01K63/045
摘要： A water circulation and filtration system for maintaining a high level of water quality in aquariums is provided. In one embodiment, the inventive system comprises a vertical water flushing tube connected to a water supply or a reverse power-head pump and having an opening positioned in proximity to the base of the aquarium. A water circulation tube and water draining tube, each of which has openings located immediately above the base of the aquarium, are provided at the opposing end of the aquarium. The water circulation tube is connected at its other end to a standard filter, while the water draining tube is connected at its other end to a hose leading to a sink, drain or external container. In a second embodiment, water from the aquarium passes through a water draining tube to a filtration chamber which is connected in series to at least one additional filtration chamber. A pump is connected to the final filtration chamber and positioned, in the direction of water flow, after the final filtration chamber. Filtered water passes from the final filtration chamber into the aquarium by means of a water draining tube.
摘要翻译： 提供了一种用于保持水族箱水质高水平的水循环和过滤系统。 在一个实施例中，本发明的系统包括连接到供水或反向动力头泵的垂直水冲洗管，并且具有位于靠近水族箱底部的开口。 在水族箱的相对端处设置有水循环管和排水管，每个管都具有位于水族箱底部正上方的开口。 水循环管的另一端连接到标准过滤器，而排水管的另一端连接到通向水槽，排水管或外部容器的软管。 在第二个实施例中，来自水族箱的水通过排水管到与至少一个额外的过滤室串联连接的过滤室。 泵连接到最终的过滤室，并在水流的方向上定位在最后的过滤室之后。 过滤的水通过排水管从最终过滤室进入水族箱。
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公开(公告)号：US06533928B1
公开(公告)日：2003-03-18
申请号：US10027956
申请日：2001-12-20
申请人： Kuniaki Terato
发明人： Kuniaki Terato
IPC分类号： A01K6304
CPC分类号： A01K63/045
摘要： A water circulation and filtration system for maintaining a high level of water quality in aquariums is provided. Preferably the system is used in conjunction with a gravel screen, which is located just above the base of the aquarium. The inventive system comprises a vertical water flushing tube connected to a water supply or a reverse power-head pump and having an opening positioned in proximity to the base of the aquarium and below the gravel screen. A water circulation tube and water draining tube, each of which have openings located immediately above the base of the aquarium and below the gravel screen, are provided at the opposing end of the aquarium. The water circulation tube is connected at its other end to a standard filter, while the water draining tube is connected at its other end to a hose leading to a sink, drain or external container.
摘要翻译： 提供了一种用于保持水族箱水质高水平的水循环和过滤系统。 优选地，该系统与位于水族箱底部正上方的砾石筛网结合使用。 本发明的系统包括连接到供水或反向动力头泵的垂直水冲洗管，并且具有位于靠近水族箱底部并且在砾石筛下方的开口。 在水族箱的相对端设置有水循环管和排水管，每个管都具有位于水族箱底部正下方并且位于砾石筛下方的开口。 水循环管的另一端连接到标准过滤器，而排水管的另一端连接到通向水槽，排水管或外部容器的软管。
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公开(公告)号：US4169051A
公开(公告)日：1979-09-25
申请号：US849960
申请日：1977-11-09
申请人： Nagayasu Satoh , Hideo Takahira , Kuniaki Terato
发明人： Nagayasu Satoh , Hideo Takahira , Kuniaki Terato
CPC分类号： B01D69/147 , A61M1/3679 , B01D15/00 , C01B31/084 , C01B31/14
摘要： A process to use coated beads-shaped activated carbon as an adsorbent in purification of the blood is disclosed. The absorbent is prepared by coating a beads-shaped activated carbon with a film-forming material. The coated beads-shaped activated carbon exhibits excellent properties with regard to the amount of the free carbon dusts, the ash to be dissolved out, the residual solvent, the degree of coagulation of the blood, and high safety, as compared with the conventional adsorbents.
摘要翻译： 公开了在净化血液中使用涂覆的珠状活性炭作为吸附剂的方法。 通过用成膜材料涂覆珠状活性炭来制备吸收剂。 与常规吸附剂相比，涂覆的珠状活性炭相对于游离碳粉的量，待溶解的灰分，残留溶剂，血液凝固程度和高安全性表现出优异的性能 。
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