发明申请
US20100305096A1 BICYCLIC PYRIMIDINE PI3K INHIBITOR COMPOUNDS SELECTIVE FOR P110 DELTA, AND METHODS OF USE
有权
用于P110 DELTA的双相PYRIMIDIN PI3K抑制剂化合物选择及使用方法
- 专利标题： BICYCLIC PYRIMIDINE PI3K INHIBITOR COMPOUNDS SELECTIVE FOR P110 DELTA, AND METHODS OF USE
- 专利标题（中）： 用于P110 DELTA的双相PYRIMIDIN PI3K抑制剂化合物选择及使用方法
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申请号： US12787613申请日： 2010-05-26
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公开(公告)号： US20100305096A1公开(公告)日： 2010-12-02
- 发明人: Georgette Castanedo , Bryan Chan , David Goldstein , Rama Kondru , Matthew Lucas , Wylie Palmer , Stephen Price , Brian Safina , Pascal Pierre Alexandre Savy , Eileen Mary Seward , Daniel P. Sutherlin , Zachary K. Sweeney
- 申请人： Georgette Castanedo , Bryan Chan , David Goldstein , Rama Kondru , Matthew Lucas , Wylie Palmer , Stephen Price , Brian Safina , Pascal Pierre Alexandre Savy , Eileen Mary Seward , Daniel P. Sutherlin , Zachary K. Sweeney
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; C07D495/04 ; C07D471/04 ; C07D473/16 ; A61K31/541 ; A61K31/55 ; A61K31/551 ; A61K31/553 ; A61P35/00 ; A61P37/00 ; A61P9/00 ; A61P31/12 ; A61P29/00 ; A61P3/00 ; A61P5/00 ; A61P25/00
摘要：
Formula I (Ia and Ib) compounds wherein (i) X1 is N and X2 is S, (ii) X1 is CR7 and X2 is S, (iii) X1 is N and X2 is NR2, or (iv) X1 is CR7 and X2 is O, including stereoisomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.