发明申请
US20100310451A1 ALTERED N-CADHERIN PROCESSING IN TUMOR CELLS BY FURIN AND PROPROTEIN CONVERTASE 5A (PC5A)
审中-公开
通过FURIN和PROPROTEIN CONVERTASE 5A（PC5A）改变肿瘤细胞中的N-CADHERIN加工
- 专利标题： ALTERED N-CADHERIN PROCESSING IN TUMOR CELLS BY FURIN AND PROPROTEIN CONVERTASE 5A (PC5A)
- 专利标题（中）： 通过FURIN和PROPROTEIN CONVERTASE 5A（PC5A）改变肿瘤细胞中的N-CADHERIN加工
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申请号： US12740654申请日： 2008-11-03
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公开(公告)号： US20100310451A1公开(公告)日： 2010-12-09
- 发明人: Deborah Maret , David R. Colman , Eugenia Gruzglin , Nabil Seidah
- 申请人： Deborah Maret , David R. Colman , Eugenia Gruzglin , Nabil Seidah
- 申请人地址： CA QC Montreal CA QC Montreal US NY New York
- 专利权人： THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARN,IRCM (INSTITUT DE RECHERCHES CLINQUES DE MONTRÉAL),MOUNT SINAI SCHOOL OF MEDICINE
- 当前专利权人： THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARN,IRCM (INSTITUT DE RECHERCHES CLINQUES DE MONTRÉAL),MOUNT SINAI SCHOOL OF MEDICINE
- 当前专利权人地址： CA QC Montreal CA QC Montreal US NY New York
- 国际申请： PCT/CA2008/001949 WO 20081103
- 主分类号： A61K51/00
- IPC分类号： A61K51/00 ; G01N33/574 ; C12Q1/68 ; A61K49/00 ; A61K49/06
摘要：
The present invention relates to a method for diagnosis and/or prognosis of cancer and for monitoring the progression of cancer and/or the therapeutic efficacy of an anti-cancer treatment in a subject by determining the molecular form of cadherin at the cell surface of cancer cells in the subject. The invention also relates to a method for preventing, inhibiting or treating cancer or its metastasis in a subject by increasing the adhesive forms of cadherin and/or decreasing the non-adhesive forms of cadherin at the cell surface. The invention also relates to a method step of determining the expression level of furin and proprotein convertase 5A (PC5A).
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