-
1.发明申请ALTERED N-CADHERIN PROCESSING IN TUMOR CELLS BY FURIN AND PROPROTEIN CONVERTASE 5A (PC5A) 审中-公开通过FURIN和PROPROTEIN CONVERTASE 5A（PC5A）改变肿瘤细胞中的N-CADHERIN加工公开(公告)号：US20100310451A1
公开(公告)日：2010-12-09
申请号：US12740654
申请日：2008-11-03
申请人： Deborah Maret , David R. Colman , Eugenia Gruzglin , Nabil Seidah
发明人： Deborah Maret , David R. Colman , Eugenia Gruzglin , Nabil Seidah
IPC分类号： A61K51/00 , G01N33/574 , C12Q1/68 , A61K49/00 , A61K49/06
CPC分类号： A61K38/482 , A61K31/7105 , C12N15/1137 , C12N2310/14 , C12Y304/21075 , C12Y304/21826 , G01N33/57492 , G01N2333/705 , G01N2333/96438
摘要： The present invention relates to a method for diagnosis and/or prognosis of cancer and for monitoring the progression of cancer and/or the therapeutic efficacy of an anti-cancer treatment in a subject by determining the molecular form of cadherin at the cell surface of cancer cells in the subject. The invention also relates to a method for preventing, inhibiting or treating cancer or its metastasis in a subject by increasing the adhesive forms of cadherin and/or decreasing the non-adhesive forms of cadherin at the cell surface. The invention also relates to a method step of determining the expression level of furin and proprotein convertase 5A (PC5A).
摘要翻译： 本发明涉及通过确定癌细胞表面的钙粘着蛋白的分子形式，在癌症的诊断和/或预后以及用于监测癌症进展和/或抗癌治疗的治疗效果的方法中 受试者的细胞。 本发明还涉及通过增加钙黏着蛋白的粘合剂形式和/或降低细胞表面的钙粘蛋白的非粘合形式来预防，抑制或治疗受试者的癌症或其转移的方法。 本发明还涉及确定弗林蛋白酶和前蛋白转化酶5A（PC5A）的表达水平的方法步骤。
-
公开(公告)号：US6025143A
公开(公告)日：2000-02-15
申请号：US476120
申请日：1995-06-07
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , C07K5/10 , C07K5/113 , C07K5/117 , C07K7/06 , C07K14/00 , C07K14/47 , C07K14/575 , C07K16/00 , C07K16/18 , C07K16/30 , C12N5/06 , C12N5/10 , C12N9/02 , C12N15/02 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/50 , G01N33/574 , G01N33/577 , G01N33/68 , A01K39/395
CPC分类号： C07K5/1021 , C07K14/47 , C07K14/575 , C07K16/18 , C07K5/1024 , G01N33/68 , A61K38/00
摘要： The present invention relates to peptides and polypeptides derived from the submaxillary gland of the rat. In particular, the present invention discloses a purified peptide of formuls:X-His-Asn-Pro-Yin which X represents a Gln or Pro-Glu residue and Y represents an OH group or residue of a basic amino acid. The present invention also relates to corresponding polyclonal and monoclonal antibodies as well as corresponding hybridomas. The products of the present invention are useful for therapeutic, diagnosis and detection purposes.
摘要翻译： 本发明涉及衍生自大鼠的下颌腺的肽和多肽。 特别地，本发明公开了一种精制肽：X-His-Asn-Pro-Yin，其X表示Gln或Pro-Glu残基，Y表示OH基团或碱性氨基酸残基。 本发明还涉及相应的多克隆和单克隆抗体以及相应的杂交瘤。 本发明的产品可用于治疗，诊断和检测目的。
-
3.发明授权Peptides and polypeptides derived from the submaxillary gland of the rat, corresponding polyclonal and monoclonal antibodies, corresponding hybridomas and uses of these products for diagnosis, for detection or therapeutic purposes 失效衍生自大鼠下颌腺的肽和多肽，相应的多克隆和单克隆抗体，相应的杂交瘤以及这些产物用于诊断，检测或治疗目的的用途
公开(公告)号：US5859189A
公开(公告)日：1999-01-12
申请号：US153277
申请日：1993-11-17
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , C07K5/10 , C07K5/113 , C07K5/117 , C07K7/06 , C07K14/00 , C07K14/47 , C07K14/575 , C07K16/00 , C07K16/18 , C07K16/30 , C12N5/06 , C12N5/10 , C12N9/02 , C12N15/02 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/50 , G01N33/574 , G01N33/577 , G01N33/68 , C07K5/00
CPC分类号： C07K5/1021 , C07K14/47 , C07K14/575 , C07K16/18 , C07K5/1024 , G01N33/68 , A61K38/00
摘要： The present invention relates to peptides and polypeptides derived from the submaxillary gland of the rat. In particular, the present invention discloses a purified peptide of formula:X--His--Asn--Pro--Yin which X represents a Gln or Pro--Glu residue and Y represents an OH group or a residue of a basic amino acid. The present invention also relates to corresponding polyclonal and monoclonal antibodies as well as corresponding hybridomas. The products of the present invention are useful for therapeutic, diagnosis and detection purposes.
摘要翻译： 本发明涉及衍生自大鼠的下颌腺的肽和多肽。 特别地，本发明公开了一种分子式为X-His-Asn-Pro-Y的纯化肽，其中X代表Gln或Pro-Glu残基，Y代表OH基团或碱性氨基酸残基。 本发明还涉及相应的多克隆和单克隆抗体以及相应的杂交瘤。 本发明的产品可用于治疗，诊断和检测目的。
-
公开(公告)号：US4607023A
公开(公告)日：1986-08-19
申请号：US644672
申请日：1984-08-27
申请人： Gaetan Thibault , Raul Garcia , Marc Cantin , Nabil Seidah , Claude Lazure , Michel Chretien
发明人： Gaetan Thibault , Raul Garcia , Marc Cantin , Nabil Seidah , Claude Lazure , Michel Chretien
摘要： Novel peptides in substantially pure form and selected from the group of peptides having the amino acid sequence:X-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Y-ZwhereinY is selected from the group consisting of -Asn, -Asn-Ser, -Asn-Ser-Phe, -Asn-Ser-Phe-Arg, and -Asn-Ser-Phe-Arg-Tyr;Z is OH or NH.sub.2 ; andX is selected from the group consisting of H, Ser-, Ser-Ser-, Arg-Ser-Ser-, Arg-Arg-Ser-Ser-, Leu-Arg-Arg-Ser-Ser, Ser-Leu-Arg-Arg-Ser-Ser-, Arg-Ser-Leu-Arg-Arg-Ser-Ser-, Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-, Gly-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser, Ala-Gly-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-, Leu-Ala-Gly-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser, and Glu-Val-Pro-Trp-Thr-Gly-Glu-Val-Asn-Pro-Ser-Gln-Arg-Asp-Gly-Gly-Ala-Leu-Gly-Arg-Gly-Pro-Trp-Asp-Pro-Ser-Asp-Arg-Ser-Ala-Leu-Lys-Ser-Lys-Leu-Arg-Ala-Leu-Leu-Ala-Gly-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-,are disclosed as having diuretic, natriuretic, vasorelaxant, hypotensive or anti-hypertensive properties.
摘要翻译： 选自具有以下氨基酸序列的肽基本上纯的形式的新型肽：X-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu -Gly-Cys-YZ，其中Y选自-Asn，-Asn-Ser，-Asn-Ser-Phe，-Asn-Ser-Phe-Arg和-Asn-Ser-Phe-Arg-Tyr ; Z是OH或NH 2; 并且X选自H，Ser-，Ser-Ser-，Arg-Ser-Ser-，Arg-Arg-Ser-Ser-，Leu-Arg-Arg-Ser-Ser，Ser-Leu-Arg -Arg-Ser-Ser-，Arg-Ser-Leu-Arg-Arg-Ser-Ser-，Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-，Gly-Pro-Arg-Ser-Leu- Arg-Arg-Ser-Ser，Ala-Gly-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-，Leu-Ala-Gly-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser ，Glu-Val-Pro-Trp-Thr-Gly-Glu-Val-Asn-Pro-Ser-Gln-Arg-Asp-Gly-Gly-Ala-Leu-Gly-Arg-Gly-Pro-Trp-Asp -Pro-Ser-Asp-Arg-Ser-Ala-Leu-Lys-Ser-Lys-Leu- Arg-Ala-Leu-Leu-Ala-Gly-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser - 被披露为具有利尿，利钠，血管舒张，降压或抗高血压的性质。
-
5.发明申请SCREENING PROTEINASE MODULATORS USING A CHIMERIC PROTEIN AND SKI-I PROPROTEIN CONVERTASE SUBSTRATES AND INHIBITORS 审中-公开筛选蛋白质调节剂使用一个重要的蛋白质和滑石蛋白质转化酶底物和抑制剂公开(公告)号：US20090130691A1
公开(公告)日：2009-05-21
申请号：US12066788
申请日：2006-09-14
CPC分类号： C12Q1/37 , C07K7/06 , C07K7/08 , C07K2319/02 , C07K2319/30 , C07K2319/42 , C07K2319/50 , C12N9/48 , C12N15/625 , G01N33/5008 , G01N33/5035 , G01N2500/00
摘要： A chimeric protein comprising in sequence a signal peptide, a first amino acid tag, a proteinase bait, a second amino acid tag, a transmembrane domain and a cytosolic domain, wherein the cytosolic (CT) domain comprises a sequence able to recycle the protein from the cellular membrane to endosomes. A cell line expressing the chimeric protein and an assay using the cell line.
摘要翻译： 一种嵌合蛋白，其序列包含信号肽，第一氨基酸标签，蛋白酶诱饵，第二氨基酸标签，跨膜结构域和胞质结构域，其中所述细胞溶质（CT）结构域包含能够将蛋白质从 细胞膜到内体。 表达嵌合蛋白的细胞系和使用细胞系的测定。
-
6.发明授权PEPTIDES AND POLYPEPTIDES DERIVED FROM THE SUBMAXILLARY GLAND OF THE RAT CORRESPONDING POLYCLONAL AND MONOCLONAL ANTIBODIES CORRESPONDING HYBRIDOMAS AND USES OF THESE PRODUCTS FOR DIAGNOSIS FOR DETECTION OR THERAPEUTIC PURPOSES 失效从相应的多肽和单克隆抗体相关的多肽和单克隆抗体衍生的肽和多肽与混合物的用途和用于诊断或治疗用途的这些产品的用途公开(公告)号：US06916607B2
公开(公告)日：2005-07-12
申请号：US09386850
申请日：1999-08-31
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , C07K5/10 , C07K5/113 , C07K5/117 , C07K7/06 , C07K14/00 , C07K14/47 , C07K14/575 , C07K16/00 , C07K16/18 , C07K16/30 , C12N5/06 , C12N5/10 , C12N9/02 , C12N15/02 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/50 , G01N33/574 , G01N33/577 , G01N33/68
CPC分类号： C07K5/1021 , A61K38/00 , C07K5/1024 , C07K14/47 , C07K14/575 , C07K16/18 , G01N33/68
摘要： The present invention relates to peptides and polypeptide derived from the submaxillary gland of the rat. In particular, the present invention discloses a purified peptide of formuls: X-His-Asn-Pro-Y in which X represents a Gln or Pro-Glu residue and Y represents an OH group or residue of a basic amino acid. The present invention also relates to corresponding polyclonal and monoclonal antibodies as well as corresponding hybridomas. The products of the present invention are useful for therapeutic, diagnosis and detection purposes.
摘要翻译： 本发明涉及源自大鼠颌下腺的肽和多肽。 特别地，本发明公开了一种精制肽：X-His-Asn-Pro-Y，其中X代表Gln或Pro-Glu残基，Y代表OH基团或碱性氨基酸残基。 本发明还涉及相应的多克隆和单克隆抗体以及相应的杂交瘤。 本发明的产品可用于治疗，诊断和检测目的。
-
7.发明申请Peptides and polypeptides derived from the submaxillary gland of the rat, corresponding polyclonal and monoclonal antibodies, corresponding hybridomas and uses of these products for diagnosis, for detection or therapeutic purposes 审中-公开衍生自大鼠下颌腺的肽和多肽，相应的多克隆和单克隆抗体，相应的杂交瘤以及这些产物用于诊断，检测或治疗目的的用途公开(公告)号：US20050153374A1
公开(公告)日：2005-07-14
申请号：US11002458
申请日：2004-12-03
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , C07K5/10 , C07K5/113 , C07K5/117 , C07K7/06 , C07K14/00 , C07K14/47 , C07K14/575 , C07K16/00 , C07K16/18 , C07K16/30 , C12N5/06 , C12N5/10 , C12N9/02 , C12N15/02 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/50 , G01N33/574 , G01N33/577 , G01N33/68
CPC分类号： C07K5/1021 , A61K38/00 , C07K5/1024 , C07K14/47 , C07K14/575 , C07K16/18 , G01N33/68
摘要： The invention relates to peptides having the formula (I): X-His-Asn-Pro-Y wherein X is a rest Gln or pyro-Glu. Y is a group OH or a rest of basic aminoacid.
摘要翻译： 本发明涉及具有式（I）的肽：X-His-Asn-Pro-Y，其中X是其余的Gln或pyro-Glu。 Y是基团OH或其余碱性氨基酸。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.011 秒)
