发明申请
- 专利标题： METHOD FOR THE SEPARATION AND PURIFICATION OF EPOTHILONES
- 专利标题（中）： 分离和纯化EPOTHILON的方法
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申请号： US12865581申请日： 2008-02-01
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公开(公告)号： US20100311796A1公开(公告)日： 2010-12-09
- 发明人: Jidong Wang , Hui Zhang , Haibin Wang , Lingping Ying , Sheng Wang , Xufang Guan , Hua Bai
- 申请人： Jidong Wang , Hui Zhang , Haibin Wang , Lingping Ying , Sheng Wang , Xufang Guan , Hua Bai
- 国际申请： PCT/CN08/00265 WO 20080201
- 主分类号： A61K31/427
- IPC分类号： A61K31/427 ; A61P35/00
摘要：
The invention discloses a method for the separation and purification of epothilones, especially discloses a method for the separation and purification of epothilones B and A using normal phase silica gel chromatography, which comprises loading the sample after dissolving the sample containing epothilones B and A with C1-C7 alkyl halide compounds or mixing the sample with silica gel, then gradient eluting silica gel column by an elution solvent of normal phase silica gel column, and finally obtaining products.
公开/授权文献
- US08906947B2 Method for the separation and purification of epothilones 公开/授权日：2014-12-09
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