公开(公告)号：US08906947B2

公开(公告)日：2014-12-09

申请号：US12865581

申请日：2008-02-01

申请人： Jidong Wang ,  Hui Zhang ,  Haibin Wang ,  Lingping Ying ,  Sheng Wang ,  Xufang Guan ,  Hua Bai

发明人： Jidong Wang ,  Hui Zhang ,  Haibin Wang ,  Lingping Ying ,  Sheng Wang ,  Xufang Guan ,  Hua Bai

IPC分类号： C07D493/04 ,  C07D417/06 ,  A61K31/427 ,  A61P35/00

CPC分类号： C07D417/06 ,  C07D493/04

摘要： The invention discloses a method for the separation and purification of epothilones, especially discloses a method for the separation and purification of epothilones B and A using normal phase silica gel chromatography, which comprises loading the sample after dissolving the sample containing epothilones B and A with C1-C7 alkyl halide compounds or mixing the sample with silica gel, then gradient eluting silica gel column by an elution solvent of normal phase silica gel column, and finally obtaining products.

摘要翻译： 本发明公开了一种分离和纯化埃坡霉素的方法，特别公开了一种使用正相硅胶色谱分离和纯化埃坡霉素B和A的方法，该方法包括在将含有埃坡霉素B和A的样品溶解于C1后加载样品 -C7烷基卤化物，或将样品与硅胶混合，然后用正相硅胶柱洗脱溶剂梯度洗脱硅胶柱，最后得到产物。

公开(公告)号：US20100311796A1

公开(公告)日：2010-12-09

申请号：US12865581

申请日：2008-02-01

申请人： Jidong Wang ,  Hui Zhang ,  Haibin Wang ,  Lingping Ying ,  Sheng Wang ,  Xufang Guan ,  Hua Bai

发明人： Jidong Wang ,  Hui Zhang ,  Haibin Wang ,  Lingping Ying ,  Sheng Wang ,  Xufang Guan ,  Hua Bai

IPC分类号： A61K31/427 ,  A61P35/00

CPC分类号： C07D417/06 ,  C07D493/04

摘要： The invention discloses a method for the separation and purification of epothilones, especially discloses a method for the separation and purification of epothilones B and A using normal phase silica gel chromatography, which comprises loading the sample after dissolving the sample containing epothilones B and A with C1-C7 alkyl halide compounds or mixing the sample with silica gel, then gradient eluting silica gel column by an elution solvent of normal phase silica gel column, and finally obtaining products.

摘要翻译： 本发明公开了一种分离和纯化埃坡霉素的方法，特别公开了一种使用正相硅胶色谱分离和纯化埃坡霉素B和A的方法，该方法包括在将含有埃坡霉素B和A的样品溶解于C1后加载样品 -C7烷基卤化物，或将样品与硅胶混合，然后用正相硅胶柱洗脱溶剂梯度洗脱硅胶柱，最后得到产物。

公开(公告)号：US20140011867A1

公开(公告)日：2014-01-09

申请号：US14005951

申请日：2011-03-25

申请人： Wensheng Xiang ,  Jidong Wang ,  Xiangjing Wang ,  Chongxi Liu ,  Dianliang Gong ,  Hua Bai

发明人： Wensheng Xiang ,  Jidong Wang ,  Xiangjing Wang ,  Chongxi Liu ,  Dianliang Gong ,  Hua Bai

IPC分类号： A01N43/22

CPC分类号： A01N43/22 ,  A01N25/00 ,  A01N25/14 ,  A01N25/24

摘要： The present invention discloses use of borrelidin for preventing and controlling phytophthora root rot of soybean. The present invention also discloses formulations of borrelidin seed coating agents and wettable powders and preparation methods thereof. Borrelidin exhibits significant effects on Phytophthora sojae. As compared with the conventional fungicide metalaxyl which is used for preventing and controlling phytophthora root rot of soybean, the mycelial growth inhibition assay indicates that the IC50 and IC95 values of borrelidin are 1/62 and 1/263, respectively, of those of metalaxyl. In the indoor pot-culture experiment, the seed coating agent and wettable powder exhibit significant controlling effects on phytophthora root rot of soybean.

摘要翻译： 本发明公开了用于预防和控制大豆根腐病的用途。 本发明还公开了硼替林霉素种子包衣剂和可湿性粉剂的制剂及其制备方法。 梭菌素对疫霉疫霉菌显示出显着的影响。 与用于预防和控制大豆根腐病的常规杀真菌剂甲霜灵相比，菌丝体生长抑制实验表明，硼替雷宁的IC50和IC95值分别为甲霜灵的IC50分别为1/62和1/263。 在室内盆培养实验中，种子包衣剂和可湿性粉剂对大豆的致瘟病根腐病显示出显着的防治效果。