发明申请
US20100324284A1 PYRROLOPYRIMIDINE DERIVATIVE AS P13K INHIBITOR AND USE THEREOF
审中-公开
作为P13K抑制剂的吡咯并嘧啶衍生物及其用途
- 专利标题： PYRROLOPYRIMIDINE DERIVATIVE AS P13K INHIBITOR AND USE THEREOF
- 专利标题（中）： 作为P13K抑制剂的吡咯并嘧啶衍生物及其用途
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申请号： US12735656申请日： 2009-02-06
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公开(公告)号： US20100324284A1公开(公告)日： 2010-12-23
- 发明人: Hirosato Ebiike , Jun Ohwada , Kohei Koyama , Takeshi Murata , Woo Sang Hong
- 申请人： Hirosato Ebiike , Jun Ohwada , Kohei Koyama , Takeshi Murata , Woo Sang Hong
- 专利权人： CHUGAI SEIYAKU KABUSHIKI KAISHA
- 当前专利权人： CHUGAI SEIYAKU KABUSHIKI KAISHA
- 优先权： JP2008-027423 20080207
- 国际申请： PCT/JP2009/052017 WO 20090206
- 主分类号： C07D417/14
- IPC分类号： C07D417/14 ; C07D413/14
摘要：
A preventive or therapeutic agent of a proliferative disease such as cancer, having superior PI3K inhibitory effects, superior cell proliferation inhibitory action as well as superior stability in a body and water solubility, is provided.A compound represented by formula (I): [wherein, Q represents a linking group represented by —X—Y—; X represents a single bond —CO—, —CONH—, —CON(C1-4 alkyl)-, —CS—, —CSNH—, —CSN(C1-4 alkyl)-, or —SO2—; Y represents a single bond, arylene or heteroarylene; provided that X and Y are not simultaneously single bonds; and R1 represents —C0-6 alkylene-(A)m-C1-6 alkyl, or C0-6 alkylene-(A)m-C0-6 alkylene-(heterocycle)] or a pharmaceutically acceptable salt thereof.
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